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dc.contributor.authorMcErlean, CMen_US
dc.contributor.authorBräuer-Krisch, Een_US
dc.contributor.authorAdamovics, Jen_US
dc.contributor.authorDoran, SJen_US
dc.date.accessioned2020-06-26T09:53:22Z
dc.date.issued2016-01en_US
dc.identifier.citationPhysics in medicine and biology, 2016, 61 (1), pp. 320 - 337en_US
dc.identifier.issn0031-9155en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3780
dc.identifier.eissn1361-6560en_US
dc.identifier.doi10.1088/0031-9155/61/1/320en_US
dc.description.abstractSynchrotron microbeam radiation therapy (MRT) is an advanced form of radiotherapy for which it is extremely difficult to provide adequate quality assurance. This may delay or limit its clinical uptake, particularly in the paediatric patient populations for whom it could be especially suitable. This study investigates the extent to which new developments in 3D dosimetry using optical computed tomography (CT) can visualise MRT dose distributions, and assesses what further developments are necessary before fully quantitative 3D measurements can be achieved. Two experiments are reported. In the first cylindrical samples of the radiochromic polymer PRESAGE(®) were irradiated with different complex MRT geometries including multiport treatments of collimated 'pencil' beams, interlaced microplanar arrays and a multiport treatment using an anthropomorphic head phantom. Samples were scanned using transmission optical CT. In the second experiment, optical CT measurements of the biologically important peak-to-valley dose ratio (PVDR) were compared with expected values from Monte Carlo simulations. The depth-of-field (DOF) of the optical CT system was characterised using a knife-edge method and the possibility of spatial resolution improvement through deconvolution of a measured point spread function (PSF) was investigated. 3D datasets from the first experiment revealed excellent visualisation of the 50 μm beams and various discrepancies from the planned delivery dose were found. The optical CT PVDR measurements were found to be consistently 30% of the expected Monte Carlo values and deconvolution of the microbeam profiles was found to lead to increased noise. The reason for the underestimation of the PVDR by optical CT was attributed to lack of spatial resolution, supported by the results of the DOF characterisation. Solutions are suggested for the outstanding challenges and the data are shown already to be useful in identifying potential treatment anomalies.en_US
dc.formatPrint-Electronicen_US
dc.format.extent320 - 337en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectHumansen_US
dc.subjectTomography, Opticalen_US
dc.subjectRadiotherapy Dosageen_US
dc.subjectX-Ray Therapyen_US
dc.subjectRadiotherapy Planning, Computer-Assisteden_US
dc.subjectSynchrotronsen_US
dc.titleAssessment of optical CT as a future QA tool for synchrotron x-ray microbeam therapy.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1088/0031-9155/61/1/320en_US
rioxxterms.licenseref.startdate2016-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfPhysics in medicine and biologyen_US
pubs.issue1en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublisheden_US
pubs.volume61en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorDoran, Simonen_US


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