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dc.contributor.authorDunlop, A
dc.contributor.authorMitchell, A
dc.contributor.authorTree, A
dc.contributor.authorBarnes, H
dc.contributor.authorBower, L
dc.contributor.authorChick, J
dc.contributor.authorGoodwin, E
dc.contributor.authorHerbert, T
dc.contributor.authorLawes, R
dc.contributor.authorMcNair, H
dc.contributor.authorMcQuaid, D
dc.contributor.authorMohajer, J
dc.contributor.authorNilawar, R
dc.contributor.authorPathmanathan, A
dc.contributor.authorSmith, G
dc.contributor.authorHanson, I
dc.contributor.authorNill, S
dc.contributor.authorOelfke, U
dc.date.accessioned2020-07-03T13:12:23Z
dc.date.issued2020-07
dc.identifier.citationClinical and translational radiation oncology, 2020, 23 pp. 35 - 42
dc.identifier.issn2405-6308
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3800
dc.identifier.eissn2405-6308en_US
dc.identifier.doi10.1016/j.ctro.2020.04.011en_US
dc.description.abstractIntroduction:MR-guided adapted radiotherapy (MRgART) using a high field MR-linac has recently become available. We report the estimated delivered fractional dose of the first five prostate cancer patients treated at our centre using MRgART and compare this to C-Arm linac daily Image Guided Radiotherapy (IGRT). Methods:Patients were treated using adapted treatment plans shaped to their daily anatomy. The treatments were recalculated on an MR image acquired immediately prior to treatment delivery in order to estimate the delivered fractional dose. C-arm linac non-adapted VMAT treatment plans were recalculated on the same MR images to estimate the fractional dose that would have been delivered using conventional radiotherapy techniques using a daily IGRT protocol. Results:95% and 93% of mandatory target coverage objectives and organ at risk dose constraints were achieved by MRgART and C-arm linac delivered dose estimates, respectively. Both delivery techniques were estimated to have achieved 98% of mandatory Organ At Risk (OAR) dose constraints whereas for the target clinical goals, 86% and 80% were achieved by MRgART and C-arm linac delivered dose estimates. Conclusions:Prostate MRgART can be delivered using the a high field MR-linac. Radiotherapy performed on a C-arm linac offers a good solution for prostate cancer patients who present with favourable anatomy at the time of reference imaging and demonstrate stable anatomy throughout the course of their treatment. For patients with critical OARs abutting target volumes on their reference image we have demonstrated the potential for a target dose coverage improvement for MRgART compared to C-arm linac treatment.
dc.formatElectronic-eCollection
dc.format.extent35 - 42
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleDaily adaptive radiotherapy for patients with prostate cancer using a high field MR-linac: Initial clinical experiences and assessment of delivered doses compared to a C-arm linac.
dc.typeJournal Article
dcterms.dateAccepted2020-04-26
rioxxterms.versionofrecord10.1016/j.ctro.2020.04.011
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-07en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfClinical and translational radiation oncology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublished
pubs.volume23en_US
pubs.embargo.termsNot known
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorOelfke, Uween
dc.contributor.icrauthorNill, Simeonen
dc.contributor.icrauthorTree, Alisonen


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