Age as an independent prognostic factor for survival of localised synovial sarcoma patients.
Abstract
Background We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients.Methods Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, and elderly) was estimated by Kaplan-Meier survival curves and multivariable Cox-proportional hazards modelling.Results A total of 461 patients had localised disease at diagnosis. The 5-year overall survival (OS) was 89.3±4.6%, 73.0±3.8%, 54.7±3.6%, and 43.0±7.0% in children (n=54), AYAs (n=148), adults (n=204), and elderly (n=55), respectively. Treatment modalities had no significant effect on survival in the univariable analysis. Multivariable analysis identified age at diagnosis, tumour localisation, and tumour size as significant factors affecting OS. Both tumour localisation and size were equally distributed over the age groups.Conclusions We show that outcome of synovial sarcoma patients significantly decreases with age regardless of primary tumour site, size, and treatment.
Collections
Subject
Humans
Sarcoma, Synovial
Registries
Survival Rate
Proportional Hazards Models
Retrospective Studies
Age Factors
Adolescent
Adult
Aged
Aged, 80 and over
Middle Aged
Child
Child, Preschool
Netherlands
Female
Male
Young Adult
Kaplan-Meier Estimate
Research team
Clinical and Translational Sarcoma
Language
eng
Date accepted
2015-10-08
License start date
2015-12
Citation
British journal of cancer, 2015, 113 (11), pp. 1602 - 1606