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dc.contributor.authorCharles-Edwards, E
dc.contributor.authorMorgan, V
dc.contributor.authorAttygalle, AD
dc.contributor.authorGiles, SL
dc.contributor.authorInd, TE
dc.contributor.authorDavis, M
dc.contributor.authorShepherd, J
dc.contributor.authorMcWhinney, N
dc.contributor.authordeSouza, NM
dc.date.accessioned2017-01-10T13:00:16Z
dc.date.issued2011-03
dc.identifier.citationGynecologic oncology, 2011, 120 (3), pp. 368 - 373
dc.identifier.issn0090-8258
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/386
dc.identifier.eissn1095-6859
dc.identifier.doi10.1016/j.ygyno.2010.10.013
dc.description.abstractObjective To evaluate the effects of previous cone biopsy and lesion size on detectability of stage 1a/1b cervical cancer using endovaginal T2- and diffusion-weighted magnetic resonance imaging.Methods One hundred and thirteen patients with cervical tumor were imaged using an endovaginal coil with T2-weighted (T2-W) and diffusion-weighted single-shot echo-planar sequences; 85 managed surgically (58 with prior cone biopsy/LLETZ) were evaluated. T2-W images and ADC maps viewed simultaneously were scored positive or negative for tumor and compared with histology at surgery. MRI tumor volumes, maximum radiological and histological dimensions were recorded. ROC analysis determined the MRI volume with optimal sensitivity/specificity for identifying tumor in those without and with prior cone biopsy/LLETZ and the maximum histological dimension for correctly identifying tumor with MRI. Mean apparent diffusion coefficients (ADCs) from tumor and adjacent normal epithelium were compared.Results Sensitivity and specificity for detecting tumor in those without (100%; 100% respectively) and with (80%; 78.9% respectively) prior cone biopsy/LLETZ were significantly different (p<0.001). Following cone biopsy/LLETZ, MRI tumor volume of 83 mm3 detected tumor with 80% sensitivity, 94.7% specificity; a 5.3mm maximal histological dimension was detected on MRI with 100% sensitivity, 100% specificity. Tumor ADCs were significantly lower (p<0.001) than paired normal epithelial tissue (median, 988×10(-6) mm2/s vs. 1564×10(-6) mm2/s) but neither tumor nor epithelial ADCs differed significantly between patients with or without prior cone biopsy/LLETZ (p=0.48 and 0.15, respectively).Conclusions Endovaginal MRI with T2- and diffusion-weighted sequences has significantly lower sensitivity and specificity for tumor detection following cone biopsy/LLETZ.
dc.formatPrint-Electronic
dc.format.extent368 - 373
dc.languageeng
dc.language.isoeng
dc.subjectHumans
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectBiopsy
dc.subjectNeoplasm Staging
dc.subjectSensitivity and Specificity
dc.subjectProspective Studies
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectUterine Cervical Neoplasms
dc.subjectFemale
dc.titleEndovaginal magnetic resonance imaging of stage 1A/1B cervical cancer with A T2- and diffusion-weighted magnetic resonance technique: effect of lesion size and previous cone biopsy on tumor detectability.
dc.typeJournal Article
dcterms.dateAccepted2010-10-11
rioxxterms.versionofrecord10.1016/j.ygyno.2010.10.013
rioxxterms.licenseref.startdate2011-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfGynecologic oncology
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublished
pubs.volume120
pubs.embargo.termsNot known
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthordeSouza, Nanditaen
dc.contributor.icrauthorGiles, Sharonen


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