dc.contributor.author | Bruna, A | |
dc.contributor.author | Rueda, OM | |
dc.contributor.author | Greenwood, W | |
dc.contributor.author | Batra, AS | |
dc.contributor.author | Callari, M | |
dc.contributor.author | Batra, RN | |
dc.contributor.author | Pogrebniak, K | |
dc.contributor.author | Sandoval, J | |
dc.contributor.author | Cassidy, JW | |
dc.contributor.author | Tufegdzic-Vidakovic, A | |
dc.contributor.author | Sammut, S-J | |
dc.contributor.author | Jones, L | |
dc.contributor.author | Provenzano, E | |
dc.contributor.author | Baird, R | |
dc.contributor.author | Eirew, P | |
dc.contributor.author | Hadfield, J | |
dc.contributor.author | Eldridge, M | |
dc.contributor.author | McLaren-Douglas, A | |
dc.contributor.author | Barthorpe, A | |
dc.contributor.author | Lightfoot, H | |
dc.contributor.author | O'Connor, MJ | |
dc.contributor.author | Gray, J | |
dc.contributor.author | Cortes, J | |
dc.contributor.author | Baselga, J | |
dc.contributor.author | Marangoni, E | |
dc.contributor.author | Welm, AL | |
dc.contributor.author | Aparicio, S | |
dc.contributor.author | Serra, V | |
dc.contributor.author | Garnett, MJ | |
dc.contributor.author | Caldas, C | |
dc.date.accessioned | 2020-08-04T13:58:18Z | |
dc.date.issued | 2016-09-22 | |
dc.identifier.citation | Cell, 2016, 167 (1), pp. 260 - 274.e22 | |
dc.identifier.issn | 0092-8674 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3894 | |
dc.identifier.eissn | 1097-4172 | |
dc.identifier.doi | 10.1016/j.cell.2016.08.041 | |
dc.description.abstract | The inter- and intra-tumor heterogeneity of breast cancer needs to be adequately captured in pre-clinical models. We have created a large collection of breast cancer patient-derived tumor xenografts (PDTXs), in which the morphological and molecular characteristics of the originating tumor are preserved through passaging in the mouse. An integrated platform combining in vivo maintenance of these PDTXs along with short-term cultures of PDTX-derived tumor cells (PDTCs) was optimized. Remarkably, the intra-tumor genomic clonal architecture present in the originating breast cancers was mostly preserved upon serial passaging in xenografts and in short-term cultured PDTCs. We assessed drug responses in PDTCs on a high-throughput platform and validated several ex vivo responses in vivo. The biobank represents a powerful resource for pre-clinical breast cancer pharmacogenomic studies (http://caldaslab.cruk.cam.ac.uk/bcape), including identification of biomarkers of response or resistance. | |
dc.format | Print-Electronic | |
dc.format.extent | 260 - 274.e22 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | CELL PRESS | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Tumor Cells, Cultured | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Mice | |
dc.subject | Breast Neoplasms | |
dc.subject | Xenograft Model Antitumor Assays | |
dc.subject | Drug Resistance, Neoplasm | |
dc.subject | Biological Specimen Banks | |
dc.subject | Female | |
dc.subject | Biomarkers, Pharmacological | |
dc.subject | High-Throughput Screening Assays | |
dc.subject | Pharmacogenomic Testing | |
dc.title | A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-08-18 | |
rioxxterms.versionofrecord | 10.1016/j.cell.2016.08.041 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2016-09-15 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Cell | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Preclinical Modelling of Paediatric Cancer Evolution | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Preclinical Modelling of Paediatric Cancer Evolution | |
pubs.publication-status | Published | |
pubs.volume | 167 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Preclinical Modelling of Paediatric Cancer Evolution | |
dc.contributor.icrauthor | Bruna Cabot, Alejandra | |
dc.contributor.icrauthor | Sammut, Stephen John | |