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dc.contributor.authorLiu, T-Hen_US
dc.contributor.authorTang, Y-Jen_US
dc.contributor.authorHuang, Yen_US
dc.contributor.authorWang, Len_US
dc.contributor.authorGuo, X-Len_US
dc.contributor.authorMi, J-Qen_US
dc.contributor.authorLiu, L-Gen_US
dc.contributor.authorZhu, Hen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorChen, Len_US
dc.contributor.authorLiu, Xen_US
dc.contributor.authorZhang, L-Hen_US
dc.contributor.authorYe, Q-Jen_US
dc.contributor.authorLi, B-Sen_US
dc.contributor.authorTang, J-Yen_US
dc.contributor.authorFord, Aen_US
dc.contributor.authorEnver, Ten_US
dc.contributor.authorLiu, Fen_US
dc.contributor.authorChen, G-Qen_US
dc.contributor.authorHong, D-Len_US
dc.date.accessioned2020-08-05T13:55:55Z
dc.date.issued2017-05
dc.identifier.citationLeukemia, 2017, 31 (5), pp. 1079 - 1086
dc.identifier.issn0887-6924
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3907
dc.identifier.eissn1476-5551
dc.identifier.doi10.1038/leu.2016.313
dc.description.abstractThe origin of cancers is associated with etiology as well as therapeutics. Several studies reveal that malignancies in children can originate in utero. However, a diagnostic approach to distinguish between cancers initiated pre- or postnatally is absent. Here we identified a transcriptional factor FEV (fifth Ewing variant) that was expressed in fetal hematopoietic cells and became silent after birth. We characterized that FEV was essential for the self-renewal of hematopoietic stem cells (HSCs). We next found that FEV was expressed in most infant leukemia samples, but seldom in adult samples, in accord with the known prenatal origins of the former. We further determined the majority of pediatric acute lymphoid leukemia (ALL) and acute myeloid leukemia (AML) were FEV positive. Moreover, FEV knockdown markedly impaired the leukemia-propagating ability of leukemic stem cells. We therefore identified FEV is unique to fetal HSCs and stably expressed in leukemic cells of prenatal origin. It may also provide a tractable therapeutic target.en_US
dc.formatPrint-Electronic
dc.format.extent1079 - 1086
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHematopoietic Stem Cellsen_US
dc.subjectCells, Cultureden_US
dc.subjectAnimalsen_US
dc.subjectHumansen_US
dc.subjectMiceen_US
dc.subjectLeukemiaen_US
dc.subjectFetal Diseasesen_US
dc.subjectDNA-Binding Proteinsen_US
dc.subjectNuclear Proteinsen_US
dc.subjectTranscription Factorsen_US
dc.subjectGene Expressionen_US
dc.subjectPregnancyen_US
dc.subjectFemaleen_US
dc.subjectLeukemia, Myeloid, Acuteen_US
dc.subjectPrecursor Cell Lymphoblastic Leukemia-Lymphomaen_US
dc.subjectHeterograftsen_US
dc.titleExpression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.
dc.typeJournal Article
dcterms.dateAccepted2016-09-29
rioxxterms.versionofrecord10.1038/leu.2016.313
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfLeukemiaen_US
pubs.issue5
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Biology of Childhood Leukaemia
pubs.publication-statusPublished
pubs.volume31en_US
pubs.embargo.termsNo embargo
icr.researchteamBiology of Childhood Leukaemiaen_US
dc.contributor.icrauthorFord, Anthonyen


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