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dc.contributor.authorWaterton, JC
dc.contributor.authorHines, CDG
dc.contributor.authorHockings, PD
dc.contributor.authorLaitinen, I
dc.contributor.authorZiemian, S
dc.contributor.authorCampbell, S
dc.contributor.authorGottschalk, M
dc.contributor.authorGreen, C
dc.contributor.authorHaase, M
dc.contributor.authorHassemer, K
dc.contributor.authorJuretschke, H-P
dc.contributor.authorKoehler, S
dc.contributor.authorLloyd, W
dc.contributor.authorLuo, Y
dc.contributor.authorMahmutovic Persson, I
dc.contributor.authorO'Connor, JPB
dc.contributor.authorOlsson, LE
dc.contributor.authorPindoria, K
dc.contributor.authorSchneider, JE
dc.contributor.authorSourbron, S
dc.contributor.authorSteinmann, D
dc.contributor.authorStrobel, K
dc.contributor.authorTadimalla, S
dc.contributor.authorTeh, I
dc.contributor.authorVeltien, A
dc.contributor.authorZhang, X
dc.contributor.authorSchütz, G
dc.date.accessioned2020-08-12T10:56:24Z
dc.date.issued2019-06
dc.identifier.citationMagnetic resonance imaging, 2019, 59 pp. 121 - 129
dc.identifier.issn0730-725X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3928
dc.identifier.eissn1873-5894
dc.identifier.doi10.1016/j.mri.2019.03.008
dc.description.abstractBackground Many translational MR biomarkers derive from measurements of the water proton longitudinal relaxation rate R 1 , but evidence for between-site reproducibility of R 1 in small-animal MRI is lacking.Objective To assess R 1 repeatability and multi-site reproducibility in phantoms for preclinical MRI.Methods R 1 was measured by saturation recovery in 2% agarose phantoms with five nickel chloride concentrations in 12 magnets at 5 field strengths in 11 centres on two different occasions within 1-13 days. R 1 was analysed in three different regions of interest, giving 360 measurements in total. Root-mean-square repeatability and reproducibility coefficients of variation (CoV) were calculated. Propagation of reproducibility errors into 21 translational MR measurements and biomarkers was estimated. Relaxivities were calculated. Dynamic signal stability was also measured.Results CoV for day-to-day repeatability (N = 180 regions of interest) was 2.34% and for between-centre reproducibility (N = 9 centres) was 1.43%. Mostly, these do not propagate to biologically significant between-centre error, although a few R 1 -based MR biomarkers were found to be quite sensitive even to such small errors in R 1 , notably in myocardial fibrosis, in white matter, and in oxygen-enhanced MRI. The relaxivity of aqueous Ni 2+ in 2% agarose varied between 0.66 s -1  mM -1 at 3 T and 0.94 s -1  mM -1 at 11.7T.Interpretation While several factors affect the reproducibility of R 1 -based MR biomarkers measured preclinically, between-centre propagation of errors arising from intrinsic equipment irreproducibility should in most cases be small. However, in a few specific cases exceptional efforts might be required to ensure R 1 -reproducibility.
dc.formatPrint-Electronic
dc.format.extent121 - 129
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectAnimals
dc.subjectMice
dc.subjectRats
dc.subjectProtons
dc.subjectOxygen
dc.subjectNickel
dc.subjectWater
dc.subjectSepharose
dc.subjectMagnetic Resonance Imaging
dc.subjectRegression Analysis
dc.subjectReproducibility of Results
dc.subjectPhantoms, Imaging
dc.subjectComputer Simulation
dc.subjectImage Processing, Computer-Assisted
dc.subjectBiomarkers
dc.titleRepeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems.
dc.typeJournal Article
dcterms.dateAccepted2019-03-08
rioxxterms.versionofrecord10.1016/j.mri.2019.03.008
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2019-06
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMagnetic resonance imaging
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging
pubs.publication-statusPublished
pubs.volume59
pubs.embargo.termsNo embargo
icr.researchteamQuantitative Biomedical Imagingen_US
dc.contributor.icrauthorO'Connor, James Patricken


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