Browsing Cancer Therapeutics by author "Turnock, Stephen"
Now showing items 1-4 of 4
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18F-meta-fluorobenzylguanidine (18F-mFBG) to monitor changes in norepinephrine transporter expression in response to therapeutic intervention in neuroblastoma models.
Turnock, S; Turton, DR; Martins, CD; Chesler, L; Wilson, TC; et al. (NATURE PORTFOLIO, 2020-12-01)Targeted radiotherapy with 131I-mIBG, a substrate of the human norepinephrine transporter (NET-1), shows promising responses in heavily pre-treated neuroblastoma (NB) patients. Combinatorial approaches that enhance 131I-mIBG ... -
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications.
Paraboschi, I; Turnock, S; Kramer-Marek, G; Musleh, L; Barisa, M; et al. (ELSEVIER SCIENCE INC, 2021-05-01)Near-InfraRed PhotoImmunoTherapy (NIR-PIT) is a novel cancer-targeted treatment effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. ... -
PET imaging to monitor NET-1 and GD2 expression in neuroblastoma
Kramer-Marek, G; Turnock, S (Institute of Cancer Research (University Of London), 2021-01-31)Within neuroblastoma (NB), approximately 50% of patients are considered high-risk, presenting widespread distant metastasis and, frequently, MYCN amplification. NB is further characterised by the selective presence of the ... -
Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [18F]AlF-Affibody Conjugates.
Da Pieve, C; Makarem, A; Turnock, S; Maczynska, J; Smith, G; et al. (MDPI, 2020-03-29)Site-selective bioconjugation of cysteine-containing peptides and proteins is currently achieved via a maleimide-thiol reaction (Michael addition). When maleimide-functionalized chelators are used and the resulting ...