Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications.
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Date
2021-05-01Author
Paraboschi, I
Turnock, S
Kramer-Marek, G
Musleh, L
Barisa, M
Anderson, J
Giuliani, S
Type
Journal Article
Metadata
Show full item recordAbstract
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) is a novel cancer-targeted treatment effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. a monoclonal antibody, moAb). Delivery of a conjugate in vivo leads to accumulation at the tumour cell surface by binding to cell surface receptors or antigens. Upon deployment of focal NIR-light, irradiation of the conjugate results in a rapid, targeted cell death. However, the mechanisms of action to produce the cytotoxic effects have yet to be fully understood. Herein, we bring together the current knowledge of NIR-PIT from preclinical and clinical studies in a variety of cancers highlighting the key unanswered research questions. Furthermore, we discuss how to enhance the local control of solid cancers using this novel treatment regimen.
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Subject
Cell Line, Tumor
Humans
Neoplasms
Photosensitizing Agents
Antibodies, Monoclonal
Immunoconjugates
Immunotherapy
Phototherapy
Research team
Preclinical Molecular Imaging
Preclinical Molecular Imaging
Language
eng
Date accepted
2021-03-26
Citation
Critical reviews in oncology/hematology, 2021, 161 pp. 103325 - ?
Publisher
ELSEVIER SCIENCE INC