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dc.contributor.authorTaprogge, Jen_US
dc.contributor.authorLeek, Fen_US
dc.contributor.authorSchurrat, Ten_US
dc.contributor.authorTran-Gia, Jen_US
dc.contributor.authorVallot, Den_US
dc.contributor.authorBardiès, Men_US
dc.contributor.authorEberlein, Uen_US
dc.contributor.authorLassmann, Men_US
dc.contributor.authorSchlögl, Sen_US
dc.contributor.authorVergara Gil, Aen_US
dc.contributor.authorMEDIRAD WP3 Investigator Teamen_US
dc.contributor.authorFlux, GDen_US
dc.date.accessioned2020-09-30T10:45:59Z
dc.date.issued2020-10-08en_US
dc.identifier.citationEJNMMI physics, 2020, 7 (1), pp. 61 - ?en_US
dc.identifier.issn2197-7364en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4089
dc.identifier.eissn2197-7364en_US
dc.identifier.doi10.1186/s40658-020-00332-9en_US
dc.description.abstract<h4>Background</h4>Differentiated thyroid cancer has been treated with radioiodine for almost 80 years, although controversial questions regarding radiation-related risks and the optimisation of treatment regimens remain unresolved. Multi-centre clinical studies are required to ensure recruitment of sufficient patients to achieve the statistical significance required to address these issues. Optimisation and standardisation of data acquisition and processing are necessary to ensure quantitative imaging and patient-specific dosimetry.<h4>Material and methods</h4>A European network of centres able to perform standardised quantitative imaging of radioiodine therapy of thyroid cancer patients was set-up within the EU consortium MEDIRAD. This network will support a concurrent series of clinical studies to determine accurately absorbed doses for thyroid cancer patients treated with radioiodine. Five SPECT(/CT) systems at four European centres were characterised with respect to their system volume sensitivity, recovery coefficients and dead time.<h4>Results</h4>System volume sensitivities of the Siemens Intevo systems (crystal thickness 3/8″) ranged from 62.1 to 73.5 cps/MBq. For a GE Discovery 670 (crystal thickness 5/8″) a system volume sensitivity of 92.2 cps/MBq was measured. Recovery coefficients measured on three Siemens Intevo systems show good agreement. For volumes larger than 10 ml, the maximum observed difference between recovery coefficients was found to be ± 0.02. Furthermore, dead-time coefficients measured on two Siemens Intevo systems agreed well with previously published dead-time values.<h4>Conclusions</h4>Results presented here provide additional support for the proposal to use global calibration parameters for cameras of the same make and model. This could potentially facilitate the extension of the imaging network for further dosimetry-based studies.en_US
dc.formatElectronicen_US
dc.format.extent61 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectMEDIRAD WP3 Investigator Teamen_US
dc.titleSetting up a quantitative SPECT imaging network for a European multi-centre dosimetry study of radioiodine treatment for thyroid cancer as part of the MEDIRAD project.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-09-29en_US
rioxxterms.versionofrecord10.1186/s40658-020-00332-9en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2020-10-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfEJNMMI physicsen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.publication-statusPublisheden_US
pubs.volume7en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamRadioisotope Physicsen_US
dc.contributor.icrauthorTaprogge, Janen_US
dc.contributor.icrauthorFlux, Glennen_US


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