Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors.

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Date
2019-02
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Author
Gorrini, C
Mak, TW
Type
Journal Article
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Abstract
In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations.
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https://repository.icr.ac.uk/handle/internal/4103
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Subject
Humans
Neoplasms
Glutathione
Amino Acid Transport System y+
Nuclear Proteins
Transcription Factors
Mutation
Research team
Target Evaluation and Molecular Therapeutics
Language
eng
License start date
2019-02
Citation
Cancer cell, 2019, 35 (2), pp. 161 - 163