Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors.
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In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This work reveals that synthesis of reduced glutathione is a metabolic dependency of cancers with ARID1A-inactivating mutations.
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Amino Acid Transport System y+
Target Evaluation and Molecular Therapeutics
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Cancer cell, 2019, 35 (2), pp. 161 - 163