PIVOTALboost: A phase III randomised controlled trial of prostate and pelvis versus prostate alone radiotherapy with or without prostate boost (CRUK/16/018).
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Date
2020-11-01Author
Syndikus, I
Cruickshank, C
Staffurth, J
Tree, A
Henry, A
Naismith, O
Mayles, H
Snelson, N
Hassan, S
Brown, S
Porta, N
Griffin, C
Hall, E
Type
Journal Article
Metadata
Show full item recordAbstract
•PIVOTALboost evaluates benefits/toxicity of pelvic node RT and focal boost dose escalation.•Unfavourable intermediate/high risk and bulky local disease are most likely to benefit.•Functional MRI imaging is used to select patients for different types of dose escalation.•HDR brachytherapy or focal dose escalation with IMRT are used as options.•Training and support is provided to reduce variations of contouring and radiotherapy planning.•The trial is recruiting patients in 38 radiotherapy centres through the UK.
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Research team
Clinical Trials & Statistics Unit
ICR-CTSU Urology and Head and Neck Trials Team
Language
eng
Date accepted
2020-08-24
License start date
2020-11
Citation
Clinical and translational radiation oncology, 2020, 25 pp. 22 - 28
Publisher
ELSEVIER IRELAND LTD