Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A Renal Cross Channel Group study.
View/ Open
Date
2017-07ICR Author
Author
Colomba, E
Le Teuff, G
Eisen, T
Stewart, GD
Fife, K
Larkin, J
Biondo, A
Pickering, L
Srinivasan, A
Boyle, H
Derosa, L
Sternberg, CN
Recine, F
Ralph, C
Saldana, C
Barthélémy, P
Bernhard, JC
Gurney, H
Verhoest, G
Vauleon, E
Bigot, P
Berger, J
Pfister, C
Gravis, G
Rodier, J-M
Culine, S
Caty, A
Rolland, F
Priou, F
Escudier, B
Albiges, L
Type
Journal Article
Metadata
Show full item recordAbstract
Background Treatment of non-clear cell renal cell carcinoma (RCC) remains controversial despite several recent prospective studies of targeted therapies (TT). Often Vascular Endothelial growth Factor (VEGF) and Mammalian Target of Rapamycin (mTOR) inhibitors are used, extrapolating the data from use of these agents in clear cell RCC.Methods We performed a retrospective data analysis within the Renal Cross Channel Group to determine metastatic chromophobe RCC (mChRCC) outcomes in the TT era. The end-points were overall response, overall survival (OS) and time to treatment failure (TTF). The two latter were estimated using the Kaplan-Meier method.Results 91 mChRCC patients from 26 centres were included. Median follow-up from the date of first metastasis was 6.1 years (range: 0-13.9). Median OS was 37.9 months (95% confidence interval [CI]: 21.4-46.8) from the diagnosis of metastatic disease. Among the 61 patients who received TT, 50 (82%) were treated with anti-angiogenic (AA) and 11 with mTOR inhibitors. Median TTF and OS in patients receiving a first line of AA was 8.7 months (95% CI: 5.2-10.9) and 22.9 months (95% CI: 17.8-49.2) versus 1.9 months (95% CI: 1.0-6.0) and 3.2 months (95% CI: 2.3-not evaluable) with mTOR inhibitors, respectively. A stratified log-rank test was used to compare AA and mTOR inhibitors TT, while controlling the effect of the International Metastatic RCC Database Consortium risk group and no significant difference between AA and mTOR inhibitors was observed for TTF (p = 0.26) or for OS (p = 0.55).Conclusion We report the largest retrospective cohort of patients with mChRCC treated with TT and no significant difference between AA and mTOR inhibitors was observed for TTF and OS.
Collections
Subject
Humans
Carcinoma, Renal Cell
Kidney Neoplasms
Angiogenesis Inhibitors
Antineoplastic Agents
Enzyme Inhibitors
Treatment Failure
Survival Analysis
Retrospective Studies
Time Factors
Adult
Aged
Middle Aged
Female
Male
Kaplan-Meier Estimate
TOR Serine-Threonine Kinases
Molecular Targeted Therapy
Research team
Melanoma and Kidney Cancer
Language
eng
Date accepted
2017-03-13
License start date
2017-07
Citation
European journal of cancer (Oxford, England : 1990), 2017, 80 pp. 55 - 62