dc.contributor.author | Khan, K | |
dc.contributor.author | Gonzalez-Exposito, R | |
dc.contributor.author | Cunningham, D | |
dc.contributor.author | Koh, D-M | |
dc.contributor.author | Woolston, A | |
dc.contributor.author | Barber, L | |
dc.contributor.author | Griffiths, B | |
dc.contributor.author | Kouvelakis, K | |
dc.contributor.author | Calamai, V | |
dc.contributor.author | Bali, M | |
dc.contributor.author | Khan, N | |
dc.contributor.author | Bryant, A | |
dc.contributor.author | Saffery, C | |
dc.contributor.author | Dearman, C | |
dc.contributor.author | Begum, R | |
dc.contributor.author | Rao, S | |
dc.contributor.author | Starling, N | |
dc.contributor.author | Watkins, D | |
dc.contributor.author | Chau, I | |
dc.contributor.author | Braconi, C | |
dc.contributor.author | Valeri, N | |
dc.contributor.author | Gerlinger, M | |
dc.contributor.author | Fotiadis, N | |
dc.date.accessioned | 2020-10-20T11:14:11Z | |
dc.date.issued | 2020-09-04 | |
dc.identifier.citation | Frontiers in oncology, 2020, 10 pp. 1634 - ? | |
dc.identifier.issn | 2234-943X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4178 | |
dc.identifier.eissn | 2234-943X | |
dc.identifier.doi | 10.3389/fonc.2020.01634 | |
dc.description.abstract | BACKGROUND: Image-guided tissue biopsies are critically important in the diagnosis and management of cancer patients. High-yield samples are also vital for biomarker and resistance mechanism discovery through molecular/genomic analyses. PATIENTS AND METHODS: All consecutive patients who underwent plugged image-guided biopsy at Royal Marsden from June 2013 until September 2016 were included in the analysis. In the next step, a second cohort of patients prospectively treated within two clinical trials (PROSPECT-C and PROSPECT-R) were assessed for the DNA yield from biopsies assessed for complex genomic analysis. RESULTS: A total of 522 plugged core biopsies were performed in 457 patients [men, 52%; median age, 63 years (range, 17-93)]. Histological diagnosis was achieved in 501 of 522 (96%) performed biopsies. Age, gender, modality, metastatic site, and seniority of the interventionist were not found to be significant factors associated with odds of failure on a logistic regression. Seventeen (3.3%) were admitted due to biopsy-related complications; nine, three, two, one, one, and one were admitted for grade I/II pain control, sepsis, vasovagal syncope, thrombosis, hematuria, and deranged liver functions, respectively; two patients with right upper quadrant pain after liver biopsy were found to have radiologically confirmed subcapsular hematoma requiring conservative treatment. One patient (0.2%) developed grade III hemorrhage following biopsy of a gastric gastrointestinal stromal tumor (GIST). Overall molecular analysis was successful in 89% (197/222 biopsies). Prospective validation in 62 biopsies gave success rates of 92.06 and 79.03% for DNA extraction of >1 μm and tmour content of >20%, respectively. CONCLUSION: The probability of diagnostic success for complex molecular analysis is increased with plugged large coaxial needle biopsy technique, which also minimizes complications and reduces hospital stay. High-yield DNA acquisition allows genomic molecular characterization for personalized medicine. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 1634 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | FRONTIERS MEDIA SA | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Diagnostic Accuracy and Safety of Coaxial System in Oncology Patients Treated in a Specialist Cancer Center With Prospective Validation Within Clinical Trial Data. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-07-27 | |
rioxxterms.versionofrecord | 10.3389/fonc.2020.01634 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2020-01 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Frontiers in oncology | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Medicine (RMH Smith Cunningham)/Medicine (RMH Smith Cunningham) (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 10 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Medicine (RMH Smith Cunningham) | |
icr.researchteam | Gastrointestinal Cancer Biology and Genomics | |
icr.researchteam | Translational Oncogenomics | |
dc.contributor.icrauthor | Woolston, Andrew | |
dc.contributor.icrauthor | Valeri, Nicola | |
dc.contributor.icrauthor | Gerlinger, Marco | |