Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network.
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Date
2020-08-19ICR Author
Author
Ludwig, H
Boccadoro, M
Moreau, P
San-Miguel, J
Cavo, M
Pawlyn, C
Zweegman, S
Facon, T
Driessen, C
Hajek, R
Dimopoulos, MA
Gay, F
Avet-Loiseau, H
Terpos, E
Zojer, N
Mohty, M
Mateos, M-V
Einsele, H
Delforge, M
Caers, J
Weisel, K
Jackson, G
Garderet, L
Engelhardt, M
van de Donk, N
Leleu, X
Goldschmidt, H
Beksac, M
Nijhof, I
Abildgaard, N
Bringhen, S
Sonneveld, P
Type
Journal Article
Metadata
Show full item recordAbstract
Vaccination is one of the most successful medical interventions that has saved the life of millions of people. Vaccination is particularly important in patients with multiple myeloma, who have an increased risk of infections due to the disease-inherent immune suppression, and because of the immune suppressive effects of therapy. Hence, all appropriate measures should be exploited, to elicit an effective immune response to common pathogens like influenza, pneumococci, varicella zoster virus, and to those bacteria and viruses (haemophilus influenzae, meningococci, and hepatitis) that frequently may pose a significant risk to patients with multiple myeloma. Patients after autologous, and specifically after allogeneic transplantation have severely reduced antibody titers, and therefore require a broader spectrum of vaccinations. Response to vaccination in myeloma often is less vigorous than in the general population, mandating either measurement of the postvaccination antibody titers and/or repeating the vaccination. Here, we compile the existing data on vaccination in multiple myeloma and provide recommendations for clinical practice.
Collections
Subject
Humans
Communicable Diseases
Multiple Myeloma
Immunosuppressive Agents
Vaccines
Vaccination
Consensus
Communicable Disease Control
Europe
Clinical Trials as Topic
Practice Guidelines as Topic
Research team
Myeloma Biology and Therapeutics
Language
eng
Date accepted
2020-08-05
License start date
2021-01
Citation
Leukemia, 2021, 35 (1), pp. 31 - 44
Publisher
SPRINGERNATURE