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dc.contributor.authorLi, N
dc.contributor.authorZhang, Y
dc.contributor.authorSidlauskas, K
dc.contributor.authorEllis, M
dc.contributor.authorEvans, I
dc.contributor.authorFrankel, P
dc.contributor.authorLau, J
dc.contributor.authorEl-Hassan, T
dc.contributor.authorGuglielmi, L
dc.contributor.authorBroni, J
dc.contributor.authorRichard-Loendt, A
dc.contributor.authorBrandner, S
dc.date.accessioned2020-11-23T12:09:29Z
dc.date.issued2018-08
dc.identifier.citationOncogene, 2018, 37 (31), pp. 4313 - 4333
dc.identifier.issn0950-9232
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4237
dc.identifier.eissn1476-5594
dc.identifier.doi10.1038/s41388-018-0277-1
dc.description.abstractTo identify biomarkers for glioma growth, invasion and progression, we used a candidate gene approach in mouse models with two complementary brain tumour phenotypes, developing either slow-growing, diffusely infiltrating gliomas or highly proliferative, non-invasive primitive neural tumours. In a microRNA screen we first identified microRNA-449a as most significantly differentially expressed between these two tumour types. miR-449a has a target dependent effect, inhibiting cell growth and migration by downregulation of CCND1 and suppressing neural phenotypes by inhibition of G protein coupled-receptor (GPR) 158. GPR158 promotes glioma stem cell differentiation and induces apoptosis and is highest expressed in the cerebral cortex and in oligodendrogliomas, lower in IDH mutant astrocytomas and lowest in the most malignant form of glioma, IDH wild-type glioblastoma. The correlation of GPR158 expression with molecular subtypes, patient survival and therapy response suggests a possible role of GPR158 as prognostic biomarker in human gliomas.
dc.formatPrint-Electronic
dc.format.extent4313 - 4333
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectCell Line, Tumor
dc.subjectStem Cells
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectGlioma
dc.subjectAstrocytoma
dc.subjectGlioblastoma
dc.subjectOligodendroglioma
dc.subjectBrain Neoplasms
dc.subjectReceptors, G-Protein-Coupled
dc.subjectTranscription Factors
dc.subjectMicroRNAs
dc.subjectApoptosis
dc.subjectCell Differentiation
dc.subjectCell Proliferation
dc.subjectCell Movement
dc.subjectDown-Regulation
dc.subjectBiomarkers, Tumor
dc.titleInhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades.
dc.typeJournal Article
dcterms.dateAccepted2018-03-28
rioxxterms.versionofrecord10.1038/s41388-018-0277-1
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfOncogene
pubs.issue31
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Cancer Stem Cell
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Cancer Stem Cell
pubs.publication-statusPublished
pubs.volume37
pubs.embargo.termsNot known
icr.researchteamCancer Stem Cellen_US
dc.contributor.icrauthorEvans, Ianen


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