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dc.contributor.authorGodden, AR
dc.contributor.authorO'Connell, RL
dc.contributor.authorBarry, PA
dc.contributor.authorKrupa, KCD
dc.contributor.authorWolf, LM
dc.contributor.authorMohammed, K
dc.contributor.authorKirby, AM
dc.contributor.authorRusby, JE
dc.date.accessioned2020-12-01T13:24:35Z
dc.date.issued2020-11
dc.identifier.citationBreast cancer (Tokyo, Japan), 2020, 27 (6), pp. 1126 - 1136
dc.identifier.issn1340-6868
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4246
dc.identifier.eissn1880-4233
dc.identifier.doi10.1007/s12282-020-01117-9
dc.description.abstractBackground Two-thirds of patients with early breast cancer undergo breast-conserving treatment (BCT). Aesthetic outcome is important and has long term implications for psychosocial wellbeing. The aesthetic goal of BCT is symmetry for which there is no gold-standard measure. Panel scoring is the most widely adopted assessment but has well-described limitations. This paper describes a model to objectively report aesthetic outcome using measures derived from 3-dimensional surface images (3D-SI).Method Objective measures and panel assessment were undertaken independently for 3D-SI of women who underwent BCT 1-5 years previously. Univariate analysis was used to test for association between measures and panel score. A forward stepwise multiple linear regression model was fitted to identify 3D measurements that jointly predicted the mean panel score. The fitted model coefficients were used to predict mean panel scores for an independent validation set then compared to the mean observed panel score.Results Very good intra-panel reliability was observed for the training and validation sets (wκ = 0.87, wκ = 0.84). Six 3D-measures were used in the multivariate model. There was a good correlation between the predicted and mean observed panel score in the training (n = 190) and validation (n = 100) sets (r = 0.68, r = 0.65). The 3D model tended to predict scores towards the median. The model was calibrated which improved the distribution of predicted scores.Conclusion A six-variable objective aesthetic outcome model for BCT has been described and validated. This can predict and could replace panel assessment, facilitating the independent and unbiased evaluation of aesthetic outcome to communicate and compare results, benchmark practice, and raise standards.
dc.formatPrint-Electronic
dc.format.extent1126 - 1136
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.title3-Dimensional objective aesthetic evaluation to replace panel assessment after breast-conserving treatment.
dc.typeJournal Article
dcterms.dateAccepted2020-05-25
rioxxterms.versionofrecord10.1007/s12282-020-01117-9
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-11
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBreast cancer (Tokyo, Japan)
pubs.issue6
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy/Breast Cancer Radiotherapy (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy/Breast Cancer Radiotherapy (hon.)
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume27
pubs.embargo.termsNo embargo
icr.researchteamBreast Cancer Radiotherapyen_US
dc.contributor.icrauthorKirby, Annaen
dc.contributor.icrauthorRusby, Jenniferen


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