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dc.contributor.authorGhidini, M
dc.contributor.authorLampis, A
dc.contributor.authorMirchev, MB
dc.contributor.authorOkuducu, AF
dc.contributor.authorRatti, M
dc.contributor.authorValeri, N
dc.contributor.authorHahne, JC
dc.date.accessioned2021-01-12T10:29:13Z
dc.date.issued2020-12-29
dc.identifier.citationGenes, 2020, 12 (1)
dc.identifier.issn2073-4425
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4278
dc.identifier.eissn2073-4425
dc.identifier.doi10.3390/genes12010033
dc.description.abstractPancreatic cancer is one of the most aggressive malignancies with limited treatment options thus resulting in high morbidity and mortality. Among all cancers, with a five-year survival rates of only 2-9%, pancreatic cancer holds the worst prognostic outcome for patients. To improve the overall survival, an earlier diagnosis and stratification of cancer patients for personalized treatment options are urgent needs. A minority of pancreatic cancers belong to the spectrum of Lynch syndrome-associated cancers and are characterized by microsatellite instability (MSI). MSI is a consequence of defective mismatch repair protein functions and it has been well characterized in other gastrointestinal tumors such as colorectal and gastric cancer. In the latter, high levels of MSI are linked to a better prognosis and to an increased benefit to immune-based therapies. Therefore, the same therapies could offer an opportunity of treatment for pancreatic cancer patients with MSI. In this review, we summarize the current knowledge about immune-based therapies and MSI in pancreatic cancer.
dc.formatElectronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleImmune-Based Therapies and the Role of Microsatellite Instability in Pancreatic Cancer.
dc.typeJournal Article
dcterms.dateAccepted2020-12-25
rioxxterms.versionofrecord10.3390/genes12010033
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-12-29
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfGenes
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.publication-statusPublished
pubs.volume12
pubs.embargo.termsNot known
icr.researchteamEvolutionary Genomics & Modellingen_US
icr.researchteamGastrointestinal Cancer Biology and Genomicsen_US
dc.contributor.icrauthorLampis, Andreaen
dc.contributor.icrauthorHahne, Jensen
dc.contributor.icrauthorValeri, Nicolaen


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0