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dc.contributor.authorRiexinger, A
dc.contributor.authorMartin, J
dc.contributor.authorWetscherek, A
dc.contributor.authorKuder, TA
dc.contributor.authorUder, M
dc.contributor.authorHensel, B
dc.contributor.authorLaun, FB
dc.date.accessioned2021-01-22T15:51:08Z
dc.date.issued2021-04
dc.identifier.citationMagnetic resonance in medicine, 2021, 85 (4), pp. 2095 - 2108
dc.identifier.issn0740-3194
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4309
dc.identifier.eissn1522-2594
dc.identifier.doi10.1002/mrm.28582
dc.description.abstractPurpose To find an optimized b-value distribution for reproducible triexponential intravoxel incoherent motion (IVIM) exams in the liver.Methods A numeric optimization of b-value distributions was performed using the triexponential IVIM equation and 27 different IVIM parameter sets. Starting with an initially optimized distribution of 6 b-values, the number of b-values was increased stepwise. Each new b-value was chosen from a set of 64 predefined b-values based on the computed summed relative mean error of the fitted triexponential IVIM parameters. This process was repeated for up to 100 b-values. In simulations and in vivo measurements, optimized b-value distributions were compared to 4 representative distributions found in literature.Results The first 16 optimized b-values were 0, 0.3, 0.3, 70, 200, 800, 70, 1, 3.5, 5, 70, 1.2, 6, 45, 1.5, and 60 in units of s/mm 2 . Low b-values were much more frequent than high b-values. The optimized b-value distribution resulted in a higher fit stability compared to distributions used in literature in both, simulation and in vivo measurements. Using more than 6 b-values, ideally 16 or more, increased the fit stability considerably.Conclusion Using optimized b-values, the fit uncertainty in triexponential IVIM can be largely reduced. Ideally, 16 or more b-values should be acquired.
dc.formatPrint-Electronic
dc.format.extent2095 - 2108
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAn optimized b-value distribution for triexponential intravoxel incoherent motion (IVIM) in the liver.
dc.typeJournal Article
dcterms.dateAccepted2020-10-13
rioxxterms.versionofrecord10.1002/mrm.28582
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMagnetic resonance in medicine
pubs.issue4
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusAccepted
pubs.volume85
pubs.embargo.termsNot known
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorWetscherek, Andreasen


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