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dc.contributor.authorHahne, JC
dc.contributor.authorLampis, A
dc.contributor.authorValeri, N
dc.date.accessioned2021-02-04T15:46:01Z
dc.date.available2021-02-04T15:46:01Z
dc.date.issued2020-10-15
dc.identifier.citationCellular and molecular life sciences : CMLS, 2020en_US
dc.identifier.issn1420-682X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4337
dc.identifier.eissn1420-9071en_US
dc.identifier.eissn1420-9071
dc.identifier.doi10.1007/s00018-020-03675-9en_US
dc.identifier.doi10.1007/s00018-020-03675-9
dc.description.abstractNon-coding RNAs are important regulators of differentiation during embryogenesis as well as key players in the fine-tuning of transcription and furthermore, they control the post-transcriptional regulation of mRNAs under physiological conditions. Deregulated expression of non-coding RNAs is often identified as one major contribution in a number of pathological conditions. Non-coding RNAs are a heterogenous group of RNAs and they represent the majority of nuclear transcripts in eukaryotes. An evolutionary highly conserved sub-group of non-coding RNAs is represented by vault RNAs, named since firstly discovered as component of the largest known ribonucleoprotein complexes called "vault". Although they have been initially described 30 years ago, vault RNAs are largely unknown and their molecular role is still under investigation. In this review we will summarize the known functions of vault RNAs and their involvement in cellular mechanisms.en_US
dc.formatPrint-Electronicen_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleVault RNAs: hidden gems in RNA and protein regulation.en_US
dc.typeJournal Article
dcterms.dateAccepted2020-10-05
rioxxterms.versionVoRen_US
rioxxterms.versionofrecord10.1007/s00018-020-03675-9en_US
rioxxterms.licenseref.startdate2020-10-15
dc.relation.isPartOfCellular and molecular life sciences : CMLSen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Evolutionary Genomics & Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.publication-statusPublisheden_US
pubs.embargo.termsNot knownen_US
icr.researchteamEvolutionary Genomics & Modelling
icr.researchteamGastrointestinal Cancer Biology and Genomics
dc.contributor.icrauthorLampis, Andreaen_US
dc.contributor.icrauthorValeri, Nicolaen_US
dc.contributor.icrauthorHahne, Jensen_US


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