dc.contributor.author | Buzan, MT | |
dc.contributor.author | Wetscherek, A | |
dc.contributor.author | Rank, CM | |
dc.contributor.author | Kreuter, M | |
dc.contributor.author | Heussel, CP | |
dc.contributor.author | Kachelrieß, M | |
dc.contributor.author | Dinkel, J | |
dc.date.accessioned | 2021-02-11T11:34:42Z | |
dc.date.available | 2021-02-11T11:34:42Z | |
dc.date.issued | 2020-09-01 | |
dc.identifier.citation | The British journal of radiology, 2020, 93 (1113), pp. 20190121 - ? | |
dc.identifier.issn | 0007-1285 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4344 | |
dc.identifier.eissn | 1748-880X | |
dc.identifier.doi | 10.1259/bjr.20190121 | |
dc.description.abstract | OBJECTIVE: To analyse delayed contrast dynamics of fibrotic lesions in interstitial lung disease (ILD) using five dimensional (5D) MRI and to correlate contrast dynamics with disease severity. METHODS: 20 patients (mean age: 71 years; M:F, 13:7), with chronic fibrosing ILD: n = 12 idiopathic pulmonary fibrosis (IPF) and n = 8 non-IPF, underwent thin-section multislice CT as part of the standard diagnostic workup and additionally MRI of the lung. 2 min after contrast injection, a radial gradient echo sequence with golden-angle spacing was acquired during 5 min of free-breathing, followed by 5D image reconstruction. Disease was categorized as severe or non-severe according to CT morphological regional severity. For each patient, 10 lesions were analysed. RESULTS: IPF lesions showed later peak enhancement compared to non-IPF (severe: p = 0.01, non-severe: p = 0.003). Severe lesions showed later peak enhancement compared to non-severe lesions, in non-IPF (p = 0.04), but not in IPF (p = 0.35). There was a tendency towards higher accumulation and washout rates in IPF compared to non-IPF in non-severe disease. Severe lesions had lower washout rate than non-severe ones in both IPF (p = 0.003) and non-IPF (p = 0.005). Continuous contrast agent accumulation, without washout, was found only in IPF lesions. CONCLUSIONS: Contrast agent dynamics are influenced by type and severity of pulmonary fibrosis, which might enable a more thorough characterisation of disease burden. The regional impairment is of particular interest in the context of antifibrotic treatments and was characterised using a non-invasive, non-irradiating, free-breathing method. ADVANCES IN KNOWLEDGE: Delayed contrast enhancement patterns allow the assessment of regional lung impairment which could represent different disease stages or phenotypes in ILD. | |
dc.format | Print-Electronic | |
dc.format.extent | 20190121 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BRITISH INST RADIOLOGY | |
dc.rights.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
dc.subject | Humans | |
dc.subject | Lung Diseases, Interstitial | |
dc.subject | Pulmonary Fibrosis | |
dc.subject | Connective Tissue Diseases | |
dc.subject | Organometallic Compounds | |
dc.subject | Contrast Media | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Vital Capacity | |
dc.subject | Severity of Illness Index | |
dc.subject | Prospective Studies | |
dc.subject | Pilot Projects | |
dc.subject | Respiration | |
dc.subject | Principal Component Analysis | |
dc.subject | Time Factors | |
dc.subject | Image Processing, Computer-Assisted | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Idiopathic Interstitial Pneumonias | |
dc.subject | Idiopathic Pulmonary Fibrosis | |
dc.subject | Multidetector Computed Tomography | |
dc.title | Delayed contrast dynamics as marker of regional impairment in pulmonary fibrosis using 5D MRI - a pilot study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 23-06-20 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1259/bjr.20190121 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2020-07-08 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | The British journal of radiology | |
pubs.issue | 1113 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.publication-status | Published | |
pubs.volume | 93 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Radiotherapy Physics Modelling | |
icr.researchteam | Radiotherapy Physics Modelling | |
dc.contributor.icrauthor | Wetscherek, Andreas | |