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dc.contributor.authorBuzan, MT
dc.contributor.authorWetscherek, A
dc.contributor.authorRank, CM
dc.contributor.authorKreuter, M
dc.contributor.authorHeussel, CP
dc.contributor.authorKachelrieß, M
dc.contributor.authorDinkel, J
dc.date.accessioned2021-02-11T11:34:42Z
dc.date.available2021-02-11T11:34:42Z
dc.date.issued2020-07-08
dc.identifier.citationThe British journal of radiology, 2020, 93 (1113), pp. 20190121 - ?
dc.identifier.issn0007-1285
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4344
dc.identifier.eissn1748-880X
dc.identifier.doi10.1259/bjr.20190121
dc.description.abstractObjective To analyse delayed contrast dynamics of fibrotic lesions in interstitial lung disease (ILD) using five dimensional (5D) MRI and to correlate contrast dynamics with disease severity.Methods 20 patients (mean age: 71 years; M:F, 13:7), with chronic fibrosing ILD: n = 12 idiopathic pulmonary fibrosis (IPF) and n = 8 non-IPF, underwent thin-section multislice CT as part of the standard diagnostic workup and additionally MRI of the lung. 2 min after contrast injection, a radial gradient echo sequence with golden-angle spacing was acquired during 5 min of free-breathing, followed by 5D image reconstruction. Disease was categorized as severe or non-severe according to CT morphological regional severity. For each patient, 10 lesions were analysed.Results IPF lesions showed later peak enhancement compared to non-IPF (severe: p = 0.01, non-severe: p = 0.003). Severe lesions showed later peak enhancement compared to non-severe lesions, in non-IPF ( p = 0.04), but not in IPF ( p = 0.35). There was a tendency towards higher accumulation and washout rates in IPF compared to non-IPF in non-severe disease. Severe lesions had lower washout rate than non-severe ones in both IPF ( p = 0.003) and non-IPF ( p = 0.005). Continuous contrast agent accumulation, without washout, was found only in IPF lesions.Conclusions Contrast agent dynamics are influenced by type and severity of pulmonary fibrosis, which might enable a more thorough characterisation of disease burden. The regional impairment is of particular interest in the context of antifibrotic treatments and was characterised using a non-invasive, non-irradiating, free-breathing method.Advances in knowledge Delayed contrast enhancement patterns allow the assessment of regional lung impairment which could represent different disease stages or phenotypes in ILD.
dc.formatPrint-Electronic
dc.format.extent20190121 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectHumans
dc.subjectLung Diseases, Interstitial
dc.subjectPulmonary Fibrosis
dc.subjectConnective Tissue Diseases
dc.subjectOrganometallic Compounds
dc.subjectContrast Media
dc.subjectMagnetic Resonance Imaging
dc.subjectVital Capacity
dc.subjectSeverity of Illness Index
dc.subjectProspective Studies
dc.subjectPilot Projects
dc.subjectRespiration
dc.subjectPrincipal Component Analysis
dc.subjectTime Factors
dc.subjectImage Processing, Computer-Assisted
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectIdiopathic Interstitial Pneumonias
dc.subjectIdiopathic Pulmonary Fibrosis
dc.subjectMultidetector Computed Tomography
dc.titleDelayed contrast dynamics as marker of regional impairment in pulmonary fibrosis using 5D MRI - a pilot study.
dc.typeJournal Article
dcterms.dateAccepted23-06-20
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1259/bjr.20190121
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2020-07-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfThe British journal of radiology
pubs.issue1113
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.publication-statusPublished
pubs.volume93
pubs.embargo.termsNot known
icr.researchteamRadiotherapy Physics Modelling
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorWetscherek, Andreasen


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