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dc.contributor.authorLakis, V
dc.contributor.authorLawlor, RT
dc.contributor.authorNewell, F
dc.contributor.authorPatch, A-M
dc.contributor.authorMafficini, A
dc.contributor.authorSadanandam, A
dc.contributor.authorKoufariotis, LT
dc.contributor.authorJohnston, RL
dc.contributor.authorLeonard, C
dc.contributor.authorWood, S
dc.contributor.authorRusev, B
dc.contributor.authorCorbo, V
dc.contributor.authorLuchini, C
dc.contributor.authorCingarlini, S
dc.contributor.authorLandoni, L
dc.contributor.authorSalvia, R
dc.contributor.authorMilella, M
dc.contributor.authorChang, D
dc.contributor.authorBailey, P
dc.contributor.authorJamieson, NB
dc.contributor.authorDuthie, F
dc.contributor.authorGingras, M-C
dc.contributor.authorMuzny, DM
dc.contributor.authorWheeler, DA
dc.contributor.authorGibbs, RA
dc.contributor.authorMilione, M
dc.contributor.authorAPGI
dc.contributor.authorARC-Net
dc.contributor.authorPederzoli, P
dc.contributor.authorSamra, JS
dc.contributor.authorGill, AJ
dc.contributor.authorJohns, AL
dc.contributor.authorPearson, JV
dc.contributor.authorBiankin, AV
dc.contributor.authorGrimmond, SM
dc.contributor.authorWaddell, N
dc.contributor.authorNones, K
dc.contributor.authorScarpa, A
dc.date.accessioned2021-04-08T10:30:29Z
dc.date.available2021-04-08T10:30:29Z
dc.date.issued2021-02-03
dc.identifier.citationCommunications biology, 2021, 4 (1), pp. 155 - ?
dc.identifier.issn2399-3642
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4500
dc.identifier.eissn2399-3642
dc.identifier.doi10.1038/s42003-020-01469-0
dc.description.abstractHere we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation. The T1 subgroup was enriched for functional tumors and ATRX, DAXX and MEN1 wild-type genotypes. The T2 subgroup contained tumors with mutations in ATRX, DAXX and MEN1 and recurrent patterns of chromosomal losses in half of the genome with no association between regions with recurrent loss and methylation levels. T2 tumors were larger and had lower methylation in the MGMT gene body, which showed positive correlation with gene expression. The T3 subgroup harboured mutations in MEN1 with recurrent loss of chromosome 11, was enriched for grade G1 tumors and showed histological parameters associated with better prognosis. Our results suggest a role for methylation in both driving tumorigenesis and potentially stratifying prognosis in PanNETs.
dc.formatElectronic
dc.format.extent155 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectAPGI
dc.subjectARC-Net
dc.titleDNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association.
dc.typeJournal Article
dcterms.dateAccepted2020-11-02
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1038/s42003-020-01469-0
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-02-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfCommunications biology
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Systems and Precision Cancer Medicine
pubs.publication-statusPublished
pubs.volume4
pubs.embargo.termsNot known
icr.researchteamSystems and Precision Cancer Medicine
icr.researchteamSystems and Precision Cancer Medicineen_US
dc.contributor.icrauthorSadanandam, Angurajen


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