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dc.contributor.authorBoon, Een_US
dc.contributor.authorvan der Graaf, WTAen_US
dc.contributor.authorGelderblom, Hen_US
dc.contributor.authorTesselaar, METen_US
dc.contributor.authorvan Es, RJJen_US
dc.contributor.authorOosting, SFen_US
dc.contributor.authorde Bree, Ren_US
dc.contributor.authorvan Meerten, Een_US
dc.contributor.authorHoeben, Aen_US
dc.contributor.authorSmeele, LEen_US
dc.contributor.authorWillems, SMen_US
dc.contributor.authorWitjes, MJHen_US
dc.contributor.authorButer, Jen_US
dc.contributor.authorBaatenburg de Jong, RJen_US
dc.contributor.authorFlucke, UEen_US
dc.contributor.authorPeer, PGMen_US
dc.contributor.authorBovée, JVMGen_US
dc.contributor.authorVan Herpen, CMLen_US
dc.date.accessioned2016-08-16T12:33:09Z
dc.date.issued2017-01en_US
dc.identifier.citationHead & neck, 2017, 39 (1), pp. 140 - 146en_US
dc.identifier.issn1043-3074en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/45
dc.identifier.eissn1097-0347en_US
dc.identifier.doi10.1002/hed.24556en_US
dc.description.abstract<h4>Background</h4>There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck.<h4>Methods</h4>All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed.<h4>Results</h4>We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively).<h4>Conclusion</h4>In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 140-146, 2017.en_US
dc.formatPrint-Electronicen_US
dc.format.extent140 - 146en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectHumansen_US
dc.subjectOsteosarcomaen_US
dc.subjectHead and Neck Neoplasmsen_US
dc.subjectNeoplasm Recurrence, Localen_US
dc.subjectChemotherapy, Adjuvanten_US
dc.subjectNeoadjuvant Therapyen_US
dc.subjectSurvival Rateen_US
dc.subjectRetrospective Studiesen_US
dc.subjectAge Factorsen_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectMiddle Ageden_US
dc.subjectNetherlandsen_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectYoung Adulten_US
dc.titleImpact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-06-24en_US
rioxxterms.versionofrecord10.1002/hed.24556en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0en_US
rioxxterms.licenseref.startdate2017-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfHead & necken_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Clinical and Translational Sarcoma
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume39en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamClinical and Translational Sarcomaen_US
dc.contributor.icrauthorvan der Graaf, Wilhelminaen_US
dc.contributor.icrauthorMarsden,en_US


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