Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults.
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Date
2017-01Author
Boon, E
van der Graaf, WTA
Gelderblom, H
Tesselaar, MET
van Es, RJJ
Oosting, SF
de Bree, R
van Meerten, E
Hoeben, A
Smeele, LE
Willems, SM
Witjes, MJH
Buter, J
Baatenburg de Jong, RJ
Flucke, UE
Peer, PGM
Bovée, JVMG
Van Herpen, CML
Type
Journal Article
Metadata
Show full item recordAbstract
Background There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck.Methods All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed.Results We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively).Conclusion In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 140-146, 2017.
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Subject
Humans
Osteosarcoma
Head and Neck Neoplasms
Neoplasm Recurrence, Local
Chemotherapy, Adjuvant
Neoadjuvant Therapy
Survival Rate
Retrospective Studies
Age Factors
Adolescent
Adult
Aged
Aged, 80 and over
Middle Aged
Netherlands
Female
Male
Young Adult
Research team
Clinical and Translational Sarcoma
Language
eng
Date accepted
2016-06-24
License start date
2017-01
Citation
Head & neck, 2017, 39 (1), pp. 140 - 146