Emerging biomarkers for PD-1 pathway cancer therapy.
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Date
2017-01Author
Lim, JS
Sundar, R
Chénard-Poirier, M
Lopez, J
Yap, TA
Type
Journal Article
Metadata
Show full item recordAbstract
The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-related toxicities and substantial financial burden. It is, therefore, critical to identify patients likely to benefit from such immunotherapies and develop strategies to differentiate responders from nonresponders early during treatment. Here we discuss the development of predictive and treatment response biomarkers for immune checkpoint inhibitors. We first examine the role of PD-L1 expression, the most extensively studied predictive biomarker of response, and further discuss emerging putative predictive biomarkers. We also detail challenges faced in the development of response assessments for immunotherapeutics and propose other biomarkers that may be useful as surrogate intermediate end points of response.
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Subject
Humans
Neoplasms
Antibodies, Monoclonal
Antigens, Neoplasm
Immunotherapy
Predictive Value of Tests
Biomarkers
B7-H1 Antigen
Nivolumab
Research team
Medicine (de Bono Prostate)
Medicine Drug Development Unit (de Bono)
Language
eng
License start date
2017-01
Citation
Biomarkers in medicine, 2017, 11 (1), pp. 53 - 67