dc.contributor.author | Campbell, JP | |
dc.contributor.author | Heaney, JLJ | |
dc.contributor.author | Pandya, S | |
dc.contributor.author | Afzal, Z | |
dc.contributor.author | Kaiser, M | |
dc.contributor.author | Owen, R | |
dc.contributor.author | Child, JA | |
dc.contributor.author | Gregory, W | |
dc.contributor.author | Morgan, GJ | |
dc.contributor.author | Jackson, GH | |
dc.contributor.author | Bunce, CM | |
dc.contributor.author | Drayson, MT | |
dc.date.accessioned | 2021-06-22T14:48:59Z | |
dc.date.available | 2021-06-22T14:48:59Z | |
dc.date.issued | 2017-09-05 | |
dc.identifier.citation | British journal of cancer, 2017, 117 (6), pp. 835 - 839 | |
dc.identifier.issn | 0007-0920 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4648 | |
dc.identifier.eissn | 1532-1827 | |
dc.identifier.doi | 10.1038/bjc.2017.229 | |
dc.description.abstract | BACKGROUND: Myeloma is consistently preceded by premalignant monoclonal gammopathy of undetermined significance (MGUS). In >5% of MGUS patients there is a second MGUS clone (biclonal gammopathy of undetermined significance; BGUS), yet, at myeloma diagnosis, presentation of biclonal gammopathy myeloma (BGMy) is considered less frequent, implying that myeloma eradicates coexisting MGUS. METHODS: In the largest study of its kind, we assessed BGMy frequency amongst 6399 newly diagnosed myeloma patients enrolled in recent UK clinical trials. RESULTS: Compared to expected prevalence (i.e., >5% of MGUS have BGUS), only 58 of 6399 (0.91%) newly diagnosed myeloma patients had BGMy, indicating myeloma typically eliminates coexistent MGUS. In these 58 BGMy cases, the MGUS plasma cell clone was greatly suppressed in size compared to typical levels observed in conventional MGUS; contrarily, the MGUS clone did not inhibit the myeloma plasma cell clone in BGMy. CONCLUSION: Myeloma eliminates the majority of competing MGUS, and when it does not, the MGUS clone is substantially reduced in size. | |
dc.format | Print-Electronic | |
dc.format.extent | 835 - 839 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0 | |
dc.subject | Humans | |
dc.subject | Multiple Myeloma | |
dc.subject | Precancerous Conditions | |
dc.subject | Disease Progression | |
dc.subject | Immunoglobulin A | |
dc.subject | Immunoglobulin G | |
dc.subject | Immunoglobulin M | |
dc.subject | Antibodies, Monoclonal | |
dc.subject | Prevalence | |
dc.subject | Analysis of Variance | |
dc.subject | Cell Size | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Monoclonal Gammopathy of Undetermined Significance | |
dc.title | Active multiple myeloma suppresses and typically eliminates coexisting MGUS. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-06-22 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1038/bjc.2017.229 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-sa/4.0 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | British journal of cancer | |
pubs.issue | 6 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.publication-status | Published | |
pubs.volume | 117 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Myeloma Group | |
icr.researchteam | Myeloma Group | |
dc.contributor.icrauthor | Kaiser, Martin | |