dc.contributor.author | Cruz-Garcia, L | |
dc.contributor.author | Badie, C | |
dc.contributor.author | Anbalagan, S | |
dc.contributor.author | Moquet, J | |
dc.contributor.author | Gothard, L | |
dc.contributor.author | O'Brien, G | |
dc.contributor.author | Somaiah, N | |
dc.contributor.author | Ainsbury, EA | |
dc.date.accessioned | 2021-06-30T11:49:20Z | |
dc.date.available | 2021-06-30T11:49:20Z | |
dc.date.issued | 2021-05-03 | |
dc.identifier.citation | Radiation oncology (London, England), 2021, 16 (1), pp. 83 - ? | |
dc.identifier.issn | 1748-717X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4652 | |
dc.identifier.eissn | 1748-717X | |
dc.identifier.doi | 10.1186/s13014-021-01807-4 | |
dc.description.abstract | BACKGROUND: This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients. METHODS: Peripheral blood samples were taken with ethical approval and informed consent from a total of 20 patients undergoing external beam radiotherapy for breast, lung, gastrointestinal or genitourinary tumours. Nanostring nCounter analysis of transcriptional changes was carried out in samples prior and 24 h post-delivery of the 1st radiotherapy fraction, just prior to the 5th or 6th fraction, and just before the last fraction. RESULTS: Statistical analysis with BRB-ArrayTools, GLM MANOVA and nSolver, revealed a radiation responsive panel of genes which varied by patient group (type of cancer) and with time since exposure (as an analogue for dose received), which may be useful as a biomarker of radiation response. CONCLUSION: Further validation in a wider group of patients is ongoing, together with work towards a full understanding of patient specific responses in support of personalised approaches to radiation medicine. | |
dc.format | Electronic | |
dc.format.extent | 83 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BMC | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | An ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-04-13 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1186/s13014-021-01807-4 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2021-05-03 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Radiation oncology (London, England) | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Breast Radiobiology | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Breast Radiobiology | |
pubs.publication-status | Published | |
pubs.volume | 16 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Translational Breast Radiobiology | |
icr.researchteam | Translational Breast Radiobiology | |
dc.contributor.icrauthor | Anbalagan, Selvakumar | |
dc.contributor.icrauthor | Gothard, Lone | |
dc.contributor.icrauthor | Somaiah, Navita | |