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dc.contributor.authorCruz-Garcia, L
dc.contributor.authorBadie, C
dc.contributor.authorAnbalagan, S
dc.contributor.authorMoquet, J
dc.contributor.authorGothard, L
dc.contributor.authorO'Brien, G
dc.contributor.authorSomaiah, N
dc.contributor.authorAinsbury, EA
dc.date.accessioned2021-06-30T11:49:20Z
dc.date.available2021-06-30T11:49:20Z
dc.date.issued2021-05-03
dc.identifier.citationRadiation oncology (London, England), 2021, 16 (1), pp. 83 - ?
dc.identifier.issn1748-717X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4652
dc.identifier.eissn1748-717X
dc.identifier.eissn1748-717Xen_US
dc.identifier.doi10.1186/s13014-021-01807-4
dc.identifier.doi10.1186/s13014-021-01807-4en_US
dc.description.abstractBackground This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients.Methods Peripheral blood samples were taken with ethical approval and informed consent from a total of 20 patients undergoing external beam radiotherapy for breast, lung, gastrointestinal or genitourinary tumours. Nanostring nCounter analysis of transcriptional changes was carried out in samples prior and 24 h post-delivery of the 1st radiotherapy fraction, just prior to the 5th or 6th fraction, and just before the last fraction.Results Statistical analysis with BRB-ArrayTools, GLM MANOVA and nSolver, revealed a radiation responsive panel of genes which varied by patient group (type of cancer) and with time since exposure (as an analogue for dose received), which may be useful as a biomarker of radiation response.Conclusion Further validation in a wider group of patients is ongoing, together with work towards a full understanding of patient specific responses in support of personalised approaches to radiation medicine.
dc.formatElectronic
dc.format.extent83 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleAn ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study.
dc.typeJournal Article
dcterms.dateAccepted2021-04-13
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1186/s13014-021-01807-4
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-05-03
rioxxterms.licenseref.startdate2021-05-03en_US
dc.relation.isPartOfRadiation oncology (London, England)
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Breast Radiobiology
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Translational Breast Radiobiology
pubs.publication-statusPublished
pubs.volume16en_US
pubs.embargo.termsNot known
icr.researchteamTranslational Breast Radiobiology
icr.researchteamTranslational Breast Radiobiologyen_US
dc.contributor.icrauthorAnbalagan, Selvakumaren
dc.contributor.icrauthorSomaiah, Navitaen


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