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dc.contributor.authorFinocchiaro, D
dc.contributor.authorGear, JI
dc.contributor.authorFioroni, F
dc.contributor.authorFlux, GD
dc.contributor.authorMurray, I
dc.contributor.authorCastellani, G
dc.contributor.authorVersari, A
dc.contributor.authorIori, M
dc.contributor.authorGrassi, E
dc.date.accessioned2021-07-26T14:04:31Z
dc.date.available2021-07-26T14:04:31Z
dc.date.issued2020-10-12
dc.identifier.citationEJNMMI physics, 2020, 7 (1), pp. 63 - ?
dc.identifier.issn2197-7364
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4693
dc.identifier.eissn2197-7364
dc.identifier.eissn2197-7364en_US
dc.identifier.doi10.1186/s40658-020-00328-5
dc.identifier.doi10.1186/s40658-020-00328-5en_US
dc.description.abstractBackground Internal dosimetry evaluation consists of a multi-step process ranging from imaging acquisition to absorbed dose calculations. Assessment of uncertainty is complicated and, for that reason, it is commonly ignored in clinical routine. However, it is essential for adequate interpretation of the results. Recently, the EANM published a practical guidance on uncertainty analysis for molecular radiotherapy based on the application of the law of propagation of uncertainty. In this study, we investigated the overall uncertainty on a sample of a patient following the EANM guidelines. The aim of this study was to provide an indication of the typical uncertainties that may be expected from performing dosimetry, to determine parameters that have the greatest effect on the accuracy of calculations and to consider the potential improvements that could be made if these effects were reduced.Results Absorbed doses and the relative uncertainties were calculated for a sample of 49 patients and a total of 154 tumours. A wide range of relative absorbed dose uncertainty values was observed (14-102%). Uncertainties associated with each quantity along the absorbed dose calculation chain (i.e. volume, recovery coefficient, calibration factor, activity, time-activity curve fitting, time-integrated activity and absorbed dose) were estimated. An equation was derived to describe the relationship between the uncertainty in the absorbed dose and the volume. The largest source of error was the VOI delineation. By postulating different values of FWHM, the impact of the imaging system spatial resolution on the uncertainties was investigated.Discussion To the best of our knowledge, this is the first analysis of uncertainty in molecular radiotherapy based on a cohort of clinical cases. Wide inter-lesion variability of absorbed dose uncertainty was observed. Hence, a proper assessment of the uncertainties associated with the calculations should be considered as a basic scientific standard. A model for a quick estimate of uncertainty without implementing the entire error propagation schema, which may be useful in clinical practice, was presented. Ameliorating spatial resolution may be in future the key factor for accurate absorbed dose assessment.
dc.formatElectronic
dc.format.extent63 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleUncertainty analysis of tumour absorbed dose calculations in molecular radiotherapy.
dc.typeJournal Article
dcterms.dateAccepted2020-09-16
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1186/s40658-020-00328-5
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-10-12
rioxxterms.licenseref.startdate2020-10-12en_US
dc.relation.isPartOfEJNMMI physics
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.publication-statusPublished
pubs.volume7en_US
pubs.embargo.termsNot known
icr.researchteamRadioisotope Physics
icr.researchteamRadioisotope Physicsen_US
dc.contributor.icrauthorMurray,en
dc.contributor.icrauthorGear, Jonathanen
dc.contributor.icrauthorFlux, Glennen


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