Show simple item record

dc.contributor.authorGear, JI
dc.contributor.authorCummings, C
dc.contributor.authorSullivan, J
dc.contributor.authorCooper-Rayner, N
dc.contributor.authorDowns, P
dc.contributor.authorMurray, I
dc.contributor.authorFlux, GD
dc.date.accessioned2021-07-26T14:16:48Z
dc.date.available2021-07-26T14:16:48Z
dc.date.issued2020-09-08
dc.identifier.citationPhysics in medicine and biology, 2020, 65 (17), pp. 175019 - ?
dc.identifier.issn0031-9155
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4698
dc.identifier.eissn1361-6560
dc.identifier.doi10.1088/1361-6560/aba40e
dc.description.abstractQuality control tests of molecular imaging systems are hampered by the complexity of phantom preparation. It is proposed that radioisotopes can be directly incorporated into photo-polymer resins. Use of the radio-polymer in a 3D printer allows phantoms with more complex and reliable activity distributions to be produced whilst simplifying source preparation. Initial tests have been performed to determine the practicality of integrating Tc-99m into a photo-polymer and example phantoms produced to test suitability for quality control. Samples of build and support resins were extracted from the print cartridges of an Objet30Pro Polyjet 3D printer. The response of the resin to external factors including ionising radiation, light and dilution with Tc-99m pertechnetate were explored. After success of the initial tests the radio-polymer was used in the production of different phantoms. Radionuclide dose calibrator and gamma camera acquisitions of the phantoms were used to test accuracy of activity concentration, print consistency, uniformity and heterogeneous reproducibility. Tomographic phantoms were also produced including a uniform hot sphere, a complex configuration of spheres and interlacing torus's and a hot rod phantom. The coefficient of variation between repeat prints of a 12 g disk phantom was 0.08%. Measured activity within the disks agreed to within 98 ± 2% of the expected activity based on initial resin concentration. Gamma camera integral uniformity measured across a 3D printed flood field phantom was 5.2% compared to 6.0% measured with a commercial Co-57 flood source. Heterogeneous distributions of activity were successfully reproduced for both 2D and 3D imaging phantoms. Count concentration across regions of heterogeneity agreed with the planned activity assigned to those regions on the phantom design. 3D printing of radioactive phantoms has been successfully demonstrated and is a promising application for quality control of Positron Emission Tomography and Single Photon Emission Computed Tomography systems.
dc.formatElectronic
dc.format.extent175019 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectTechnetium
dc.subjectImaging, Three-Dimensional
dc.subjectCalibration
dc.subjectReproducibility of Results
dc.subjectPhantoms, Imaging
dc.subjectMolecular Imaging
dc.subjectPrinting, Three-Dimensional
dc.titleRadioactive 3D printing for the production of molecular imaging phantoms.
dc.typeJournal Article
dcterms.dateAccepted2020-07-08
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1088/1361-6560/aba40e
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-09-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPhysics in medicine and biology
pubs.issue17
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics/Radioisotope Physics (hon.)
pubs.publication-statusPublished
pubs.volume65
pubs.embargo.termsNo embargo
icr.researchteamRadioisotope Physics
icr.researchteamRadioisotope Physicsen_US
dc.contributor.icrauthorMurray,en
dc.contributor.icrauthorGear, Jonathanen
dc.contributor.icrauthorFlux, Glennen


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0