dc.contributor.author | Lampis, A | |
dc.contributor.author | Ghidini, M | |
dc.contributor.author | Ratti, M | |
dc.contributor.author | Mirchev, MB | |
dc.contributor.author | Okuducu, AF | |
dc.contributor.author | Valeri, N | |
dc.contributor.author | Hahne, JC | |
dc.date.accessioned | 2021-07-27T14:26:44Z | |
dc.date.available | 2021-07-27T14:26:44Z | |
dc.date.issued | 2020-09-01 | |
dc.identifier | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000669888000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4b848928d1c3e5c86d298abb68475f9 | |
dc.identifier | ARTN 22 | |
dc.identifier.citation | GASTROINTESTINAL DISORDERS, 2020, 2 (3), pp. 212 - 235 (24) | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4702 | |
dc.identifier.eissn | 2624-5647 | |
dc.identifier.doi | 10.3390/gidisord2030022 | |
dc.description.abstract | <jats:p>Circulating tumour DNAs and non-coding RNAs present in body fluids have been under investigation as tools for cancer diagnosis, disease monitoring, and prognosis for many years. These so-called liquid biopsies offer the opportunity to obtain information about the molecular make-up of a cancer in a minimal invasive way and offer the possibility to implement theranostics for precision oncology. Furthermore, liquid biopsies could overcome the limitations of tissue biopsies in capturing the complexity of tumour heterogeneity within the primary cancer and among different metastatic sites. Liquid biopsies may also be implemented to detect early tumour formation or to monitor cancer relapse of response to therapy with greater sensitivity compared with the currently available protein-based blood biomarkers. Most colorectal cancers are often diagnosed at late stages and have a high mortality rate. Hence, biomolecules as nucleic acids present in liquid biopsies might have prognostic potential and could serve as predictive biomarkers for chemotherapeutic regimens. This review will focus on the role of circulating tumour DNAs and non-coding RNAs as diagnostic, prognostic, and predictive biomarkers in the context of colorectal cancer.</jats:p> | |
dc.format.extent | 212 - 235 (24) | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | MDPI | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Science & Technology | |
dc.subject | Life Sciences & Biomedicine | |
dc.subject | Gastroenterology & Hepatology | |
dc.subject | colorectal cancer | |
dc.subject | liquid biopsy | |
dc.subject | microRNA | |
dc.subject | circularRNA | |
dc.subject | long non-coding RNA | |
dc.subject | circulating cell-free tumour DNA | |
dc.subject | biomarker | |
dc.subject | POLYMERASE-CHAIN-REACTION | |
dc.subject | CELL-FREE DNA | |
dc.subject | COLON-CANCER | |
dc.subject | STAGE-II | |
dc.subject | MOLECULAR-DETECTION | |
dc.subject | MESSENGER-RNAS | |
dc.subject | CARCINOEMBRYONIC ANTIGEN | |
dc.subject | PROGNOSTIC-SIGNIFICANCE | |
dc.subject | PREDICTS SURVIVAL | |
dc.subject | DIAGNOSTIC-VALUE | |
dc.title | Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-07-21 | |
rioxxterms.version | NA | |
rioxxterms.versionofrecord | 10.3390/gidisord2030022 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2020-09-01 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | GASTROINTESTINAL DISORDERS | |
pubs.issue | 3 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics | |
pubs.publication-status | Published | |
pubs.volume | 2 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Gastrointestinal Cancer Biology and Genomics | |
icr.researchteam | Gastrointestinal Cancer Biology and Genomics | |
dc.contributor.icrauthor | Lampis, Andrea | |
dc.contributor.icrauthor | Valeri, Nicola | |
dc.contributor.icrauthor | Hahne, Jens | |