Show simple item record

dc.contributor.authorCraig, AJ
dc.contributor.authorMurray, I
dc.contributor.authorDenis-Bacelar, AM
dc.contributor.authorRojas, B
dc.contributor.authorGear, JI
dc.contributor.authorHossen, L
dc.contributor.authorMaenhout, A
dc.contributor.authorKhan, N
dc.contributor.authorFlux, GD
dc.date.accessioned2021-07-27T14:29:42Z
dc.date.available2021-07-27T14:29:42Z
dc.date.issued2021-07-30
dc.identifier.citationPhysica Medica: an international journal devoted to the applications of physics to medicine and biology
dc.identifier.issn1120-1797
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4703
dc.description.abstractPURPOSE: The aims of this study were to develop and apply a method to correct for the differences in partial volume effects of pre-therapy Technetium-99 m (99mTc)-MAA SPECT and post-therapy Yttrium-90 (90Y) bremsstrahlung SPECT imaging in selective internal radiation therapy, and to use this method to improve quantitative comparison of predicted and delivered 90Y absorbed doses. METHODS: The spatial resolution of 99mTc SPECT data was converted to that of 90Y SPECT data using a function calculated from 99mTc and 90Y point spread functions. This resolution conversion method (RCM) was first applied to 99mTc and 90Y SPECT phantom data to validate the method, and then to clinical data to assess the power of 99mTc SPECT imaging to predict the therapeutic absorbed dose. RESULTS: The maximum difference between absorbed doses to phantom spheres was 178%. This was reduced to 27% after the RCM was applied. The clinical data demonstrated differences within 38% for mean absorbed doses delivered to the normal liver, which were reduced to 20% after application of the RCM. Analysis of clinical data showed that therapeutic absorbed doses delivered to tumours greater than 100 cm3 were predicted to within 52%, although there were differences of up to 210% for smaller tumours, even after the RCM was applied. CONCLUSIONS: The RCM was successfully verified using phantom data. Analysis of the clinical data established that the 99mTc pre-therapy imaging was predictive of the 90Y absorbed dose to the normal liver to within 20%, but had poor predictability for tumours smaller than 100 cm3.
dc.languageeng
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleComparison of 90Y SIRT predicted and delivered absorbed doses using a PSF conversion method.
dc.typeJournal Article
dcterms.dateAccepted2021-07-20
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2021-07-20
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfPhysica Medica: an international journal devoted to the applications of physics to medicine and biology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.publication-statusIn preparation
pubs.embargo.termsNot known
icr.researchteamRadioisotope Physics
dc.contributor.icrauthorCraig, Allison
dc.contributor.icrauthorGear, Jonathan


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0