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dc.contributor.authorGillessen, S
dc.contributor.authorSauvé, N
dc.contributor.authorCollette, L
dc.contributor.authorDaugaard, G
dc.contributor.authorde Wit, R
dc.contributor.authorAlbany, C
dc.contributor.authorTryakin, A
dc.contributor.authorFizazi, K
dc.contributor.authorStahl, O
dc.contributor.authorGietema, JA
dc.contributor.authorDe Giorgi, U
dc.contributor.authorCafferty, FH
dc.contributor.authorHansen, AR
dc.contributor.authorTandstad, T
dc.contributor.authorHuddart, RA
dc.contributor.authorNecchi, A
dc.contributor.authorSweeney, CJ
dc.contributor.authorGarcia-Del-Muro, X
dc.contributor.authorHeng, DYC
dc.contributor.authorLorch, A
dc.contributor.authorChovanec, M
dc.contributor.authorWinquist, E
dc.contributor.authorGrimison, P
dc.contributor.authorFeldman, DR
dc.contributor.authorTerbuch, A
dc.contributor.authorHentrich, M
dc.contributor.authorBokemeyer, C
dc.contributor.authorNegaard, H
dc.contributor.authorFankhauser, C
dc.contributor.authorShamash, J
dc.contributor.authorVaughn, DJ
dc.contributor.authorSternberg, CN
dc.contributor.authorHeidenreich, A
dc.contributor.authorBeyer, J
dc.contributor.authorInternational Germ Cell Cancer Classification Update Consortium
dc.date.accessioned2021-08-03T14:27:04Z
dc.date.available2021-08-03T14:27:04Z
dc.identifier.citationJournal of clinical oncology : official journal of the American Society of Clinical Oncology, 2021, 39 (14), pp. 1563 - 1574
dc.identifier.issn0732-183X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4718
dc.identifier.eissn1527-7755
dc.identifier.eissn1527-7755en_US
dc.identifier.doi10.1200/jco.20.03296
dc.identifier.doi10.1200/jco.20.03296en_US
dc.description.abstractPurpose The classification of the International Germ Cell Cancer Collaborative Group (IGCCCG) plays a pivotal role in the management of metastatic germ cell tumors but relies on data of patients treated between 1975 and 1990.Materials and methods Data on 9,728 men with metastatic nonseminomatous germ cell tumors treated with cisplatin- and etoposide-based first-line chemotherapy between 1990 and 2013 were collected from 30 institutions or collaborative groups in Europe, North America, and Australia. Clinical trial and registry data were included. Primary end points were progression-free survival (PFS) and overall survival (OS). The survival estimates were updated for the current era. Additionally, a novel prognostic model for PFS was developed in 3,543 patients with complete information on potentially relevant variables. The results were validated in an independent data set.Results Compared with the original IGCCCG publication, 5-year PFS remained similar in patients with good prognosis with 89% (87%-91%) versus 90% (95% CI, 89 to 91), but the 5-year OS increased from 92% (90%-94%) to 96% (95%-96%). In patients with intermediate prognosis, PFS remained similar with 75% (71%-79%) versus 78% (76%-80%) and the OS increased from 80% (76%-84%) to 89% (88%-91%). In patients with poor prognosis, the PFS increased from 41% (95% CI, 35 to 47) to 54% (95% CI, 52 to 56) and the OS from 48% (95% CI, 42 to 54) to 67% (95% CI, 65 to 69). A more granular prognostic model was developed and independently validated. This model identified a new cutoff of lactate dehydrogenase at a 2.5 upper limit of normal and increasing age and presence of lung metastases as additional adverse prognostic factors. An online calculator is provided (https://www.eortc.org/IGCCCG-Update).Conclusion The IGCCCG Update model improves individual prognostication in metastatic nonseminomatous germ cell tumors. Increasing age and lung metastases add granularity to the original IGCCCG classification as adverse prognostic factors.
dc.formatPrint-Electronic
dc.format.extent1563 - 1574
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectInternational Germ Cell Cancer Classification Update Consortium
dc.titlePredicting Outcomes in Men With Metastatic Nonseminomatous Germ Cell Tumors (NSGCT): Results From the IGCCCG Update Consortium.
dc.typeJournal Article
dcterms.dateAccepted2021-02-01
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1200/jco.20.03296
dc.relation.isPartOfJournal of clinical oncology : official journal of the American Society of Clinical Oncology
pubs.issue14
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.publication-statusPublished
pubs.volume39en_US
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Huddart)
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
dc.contributor.icrauthorHuddart, Roberten


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