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dc.contributor.authorAndreassen, CN
dc.contributor.authorRosenstein, BS
dc.contributor.authorKerns, SL
dc.contributor.authorOstrer, H
dc.contributor.authorDe Ruysscher, D
dc.contributor.authorCesaretti, JA
dc.contributor.authorBarnett, GC
dc.contributor.authorDunning, AM
dc.contributor.authorDorling, L
dc.contributor.authorWest, CML
dc.contributor.authorBurnet, NG
dc.contributor.authorElliott, R
dc.contributor.authorColes, C
dc.contributor.authorHall, E
dc.contributor.authorFachal, L
dc.contributor.authorVega, A
dc.contributor.authorGómez-Caamaño, A
dc.contributor.authorTalbot, CJ
dc.contributor.authorSymonds, RP
dc.contributor.authorDe Ruyck, K
dc.contributor.authorThierens, H
dc.contributor.authorOst, P
dc.contributor.authorChang-Claude, J
dc.contributor.authorSeibold, P
dc.contributor.authorPopanda, O
dc.contributor.authorOvergaard, M
dc.contributor.authorDearnaley, D
dc.contributor.authorSydes, MR
dc.contributor.authorAzria, D
dc.contributor.authorKoch, CA
dc.contributor.authorParliament, M
dc.contributor.authorBlackshaw, M
dc.contributor.authorSia, M
dc.contributor.authorFuentes-Raspall, MJ
dc.contributor.authorRamon Y Cajal, T
dc.contributor.authorBarnadas, A
dc.contributor.authorVesprini, D
dc.contributor.authorGutiérrez-Enríquez, S
dc.contributor.authorMollà, M
dc.contributor.authorDíez, O
dc.contributor.authorYarnold, JR
dc.contributor.authorOvergaard, J
dc.contributor.authorBentzen, SM
dc.contributor.authorAlsner, J
dc.contributor.authorInternational Radiogenomics Consortium (RgC)
dc.date.accessioned2017-03-09T14:30:06Z
dc.date.issued2016-12
dc.identifier.citationRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, 121 (3), pp. 431 - 439
dc.identifier.issn0167-8140
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/483
dc.identifier.eissn1879-0887
dc.identifier.doi10.1016/j.radonc.2016.06.017
dc.description.abstractPurpose Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.Materials and methods The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity.Results For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds ratios of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance.Conclusion This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.
dc.formatPrint-Electronic
dc.format.extent431 - 439
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectInternational Radiogenomics Consortium (RgC)
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectProstatic Neoplasms
dc.subjectRadiation Injuries
dc.subjectGenetic Predisposition to Disease
dc.subjectRadiotherapy
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectGenotype
dc.subjectHeterozygote
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectRadiation Tolerance
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectAtaxia Telangiectasia Mutated Proteins
dc.titleIndividual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.
dc.typeJournal Article
dcterms.dateAccepted2016-06-29
rioxxterms.versionofrecord10.1016/j.radonc.2016.06.017
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-12
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
pubs.issue3
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.publication-statusPublished
pubs.volume121en_US
pubs.embargo.termsNot known
icr.researchteamICR-CTSU Urology and Head and Neck Trials Teamen_US
icr.researchteamClinical Academic Radiotherapy (Dearnaley)en_US
dc.contributor.icrauthorDearnaley, Daviden
dc.contributor.icrauthorYarnold, Johnen
dc.contributor.icrauthorHall, Emmaen


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