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dc.contributor.authorAndreassen, CNen_US
dc.contributor.authorRosenstein, BSen_US
dc.contributor.authorKerns, SLen_US
dc.contributor.authorOstrer, Hen_US
dc.contributor.authorDe Ruysscher, Den_US
dc.contributor.authorCesaretti, JAen_US
dc.contributor.authorBarnett, GCen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorDorling, Len_US
dc.contributor.authorWest, CMLen_US
dc.contributor.authorBurnet, NGen_US
dc.contributor.authorElliott, Ren_US
dc.contributor.authorColes, Cen_US
dc.contributor.authorHall, Een_US
dc.contributor.authorFachal, Len_US
dc.contributor.authorVega, Aen_US
dc.contributor.authorGómez-Caamaño, Aen_US
dc.contributor.authorTalbot, CJen_US
dc.contributor.authorSymonds, RPen_US
dc.contributor.authorDe Ruyck, Ken_US
dc.contributor.authorThierens, Hen_US
dc.contributor.authorOst, Pen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorSeibold, Pen_US
dc.contributor.authorPopanda, Oen_US
dc.contributor.authorOvergaard, Men_US
dc.contributor.authorDearnaley, Den_US
dc.contributor.authorSydes, MRen_US
dc.contributor.authorAzria, Den_US
dc.contributor.authorKoch, CAen_US
dc.contributor.authorParliament, Men_US
dc.contributor.authorBlackshaw, Men_US
dc.contributor.authorSia, Men_US
dc.contributor.authorFuentes-Raspall, MJen_US
dc.contributor.authorRamon Y Cajal, Ten_US
dc.contributor.authorBarnadas, Aen_US
dc.contributor.authorVesprini, Den_US
dc.contributor.authorGutiérrez-Enríquez, Sen_US
dc.contributor.authorMollà, Men_US
dc.contributor.authorDíez, Oen_US
dc.contributor.authorYarnold, JRen_US
dc.contributor.authorOvergaard, Jen_US
dc.contributor.authorBentzen, SMen_US
dc.contributor.authorAlsner, Jen_US
dc.contributor.authorInternational Radiogenomics Consortium (RgC)en_US
dc.date.accessioned2017-03-09T14:30:06Z
dc.date.issued2016-12en_US
dc.identifier.citationRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, 121 (3), pp. 431 - 439en_US
dc.identifier.issn0167-8140en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/483
dc.identifier.eissn1879-0887en_US
dc.identifier.doi10.1016/j.radonc.2016.06.017en_US
dc.description.abstractPURPOSE:Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium. MATERIALS AND METHODS:The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity. RESULTS:For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds ratios of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance. CONCLUSION:This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.en_US
dc.formatPrint-Electronicen_US
dc.format.extent431 - 439en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectInternational Radiogenomics Consortium (RgC)en_US
dc.subjectHumansen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectProstatic Neoplasmsen_US
dc.subjectRadiation Injuriesen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectRadiotherapyen_US
dc.subjectOdds Ratioen_US
dc.subjectRisk Factorsen_US
dc.subjectGenotypeen_US
dc.subjectHeterozygoteen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectAllelesen_US
dc.subjectRadiation Toleranceen_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectAtaxia Telangiectasia Mutated Proteinsen_US
dc.titleIndividual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients.en_US
dc.typeJournal Article
dcterms.dateAccepted2016-06-29en_US
rioxxterms.versionofrecord10.1016/j.radonc.2016.06.017en_US
rioxxterms.licenseref.startdate2016-12en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Dearnaley)
pubs.publication-statusPublisheden_US
pubs.volume121en_US
pubs.embargo.termsNot knownen_US
icr.researchteamICR-CTSU Urology and Head and Neck Trials Teamen_US
icr.researchteamClinical Academic Radiotherapy (Dearnaley)en_US
dc.contributor.icrauthorDearnaley, Daviden_US
dc.contributor.icrauthorYarnold, Johnen_US
dc.contributor.icrauthorHall, Emmaen_US


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