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dc.contributor.authorPortner, R
dc.contributor.authorBajaj, A
dc.contributor.authorElumalai, T
dc.contributor.authorHuddart, R
dc.contributor.authorMurthy, V
dc.contributor.authorNightingale, H
dc.contributor.authorPatel, K
dc.contributor.authorSargos, P
dc.contributor.authorSong, Y
dc.contributor.authorHoskin, P
dc.contributor.authorChoudhury, A
dc.date.accessioned2021-11-03T15:26:35Z
dc.date.available2021-11-03T15:26:35Z
dc.date.issued2021-08-19
dc.identifier.citationClinical and translational radiation oncology, 2021, 31 pp. 1 - 7
dc.identifier.issn2405-6308
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4872
dc.identifier.eissn2405-6308
dc.identifier.doi10.1016/j.ctro.2021.08.003
dc.description.abstractBladder preservation with trimodality treatment (TMT) is an alternative strategy to radical cystectomy (RC) for the management of localised muscle invasive bladder cancer (MIBC). TMT comprises of transurethral resection of the bladder tumour (TURBT) followed by radiotherapy with concurrent radiosensitisation. TMT studies have shown neo-adjuvant chemotherapy with cisplatin-based regimens is often given to further improve survival outcomes. A hypofractionated radiotherapy regimen is preferable due to its non-inferiority in local control and late toxicities. Radiosensitisation can comprise concurrent chemotherapy (with gemcitabine, cisplatin or combination fluorouracil and mitomycin), CON (carbogen and nicotinomide) or hyperthermic treatment. Radiotherapy techniques are continuously improving and becoming more personalised. As the bladder is a mobile structure subject to volumetric changes from filling, an adaptive approach can optimise bladder coverage and reduce dose to normal tissue. Adaptive radiotherapy (ART) is an evolving field that aims to overcome this. Improved knowledge of tumour biology and advances in imaging techniques aims to further optimise and personalise treatment.
dc.formatElectronic-eCollection
dc.format.extent1 - 7
dc.languageeng
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleA practical approach to bladder preservation with hypofractionated radiotherapy for localised muscle-invasive bladder cancer.
dc.typeJournal Article
dcterms.dateAccepted2021-08-03
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1016/j.ctro.2021.08.003
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfClinical and translational radiation oncology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.publication-statusAccepted
pubs.volume31
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Huddart)
dc.contributor.icrauthorHuddart, Robert


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