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dc.contributor.authorMele, T
dc.contributor.authorReid, A
dc.contributor.authorHuddart, R
dc.date.accessioned2021-11-03T15:39:31Z
dc.date.available2021-11-03T15:39:31Z
dc.identifier.citationFaculty reviews, 2021, 10 pp. 67 - ?
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4873
dc.identifier.eissn2732-432X
dc.identifier.doi10.12703/r/10-67
dc.description.abstractTesticular germ cell tumours (TGCTs) are the most common solid tumours in young men and have an excellent overall cure rate and prognosis. In most patients, localised disease is cured by surgery alone, and a minority of patients receive short-course adjuvant chemotherapy to reduce the risk of further relapse. Also, in about 80% of patients, metastatic disease can be cured by systemic cisplatin-based chemotherapy. Unfortunately, for a proportion of patients, the disease exhibits platinum resistance and relapse occurs. Despite further lines of systemic treatment, cure can be difficult to achieve in these patients and ultimately about 20% of them will die from disease progression. Addressing the mechanisms underpinning platinum resistance is critical to improving the survival and chances of cure for these patients. This review describes the latest advances in TGCT research, focusing on the identification of novel biomarkers, genetic characteristics and exploring novel treatments.
dc.formatElectronic-eCollection
dc.format.extent67 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleRecent advances in testicular germ cell tumours.
dc.typeJournal Article
dcterms.dateAccepted2021-01-01
rioxxterms.versionVoR
rioxxterms.versionofrecord10.12703/r/10-67
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfFaculty reviews
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.publication-statusPublished
pubs.volume10
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Huddart)
dc.contributor.icrauthorMele, Teresaen_US
dc.contributor.icrauthorHuddart, Roberten_US


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Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0