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dc.contributor.authorCagnet, S
dc.contributor.authorAtaca, D
dc.contributor.authorSflomos, G
dc.contributor.authorAouad, P
dc.contributor.authorSchuepbach-Mallepell, S
dc.contributor.authorHugues, H
dc.contributor.authorKrust, A
dc.contributor.authorAyyanan, A
dc.contributor.authorScabia, V
dc.contributor.authorBrisken, C
dc.date.accessioned2021-11-19T09:17:08Z
dc.date.available2021-11-19T09:17:08Z
dc.date.issued2018-11-09
dc.identifier.citationNature communications, 2018, 9 (1), pp. 4723 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4885
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-018-07175-0
dc.description.abstractOestrogen receptor α (ERα) is a transcription factor with ligand-independent and ligand-dependent activation functions (AF)-1 and -2. Oestrogens control postnatal mammary gland development acting on a subset of mammary epithelial cells (MECs), termed sensor cells, which are ERα-positive by immunohistochemistry (IHC) and secrete paracrine factors, which stimulate ERα-negative responder cells. Here we show that deletion of AF-1 or AF-2 blocks pubertal ductal growth and subsequent development because both are required for expression of essential paracrine mediators. Thirty percent of the luminal cells are ERα-negative by IHC but express Esr1 transcripts. This low level ERα expression through AF-2 is essential for cell expansion during puberty and growth-inhibitory during pregnancy. Cell-intrinsic ERα is not required for cell proliferation nor for secretory differentiation but controls transcript levels of cell motility and cell adhesion genes and a stem cell and epithelial mesenchymal transition (EMT) signature identifying ERα as a key regulator of mammary epithelial cell plasticity.
dc.formatElectronic
dc.format.extent4723 - ?
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectEndocrine System
dc.subjectEpithelium
dc.subjectMammary Glands, Animal
dc.subjectEpithelial Cells
dc.subjectAnimals
dc.subjectMice, Inbred C57BL
dc.subjectSteroids
dc.subjectEstrogen Receptor alpha
dc.subjectRNA, Messenger
dc.subjectCell Proliferation
dc.subjectGene Expression Regulation
dc.subjectStructure-Activity Relationship
dc.subjectPregnancy
dc.subjectPhenotype
dc.subjectFemale
dc.subjectProtein Domains
dc.titleOestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium.
dc.typeJournal Article
dcterms.dateAccepted2018-10-15
rioxxterms.versionofrecord10.1038/s41467-018-07175-0
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-11-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrine control mechanisms
pubs.publication-statusPublished
pubs.volume9
pubs.embargo.termsNot known
icr.researchteamEndocrine control mechanisms
dc.contributor.icrauthorBrisken, Cathrin


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