dc.contributor.author | Begum, P | |
dc.contributor.author | Goldin, RD | |
dc.contributor.author | Possamai, LA | |
dc.contributor.author | Popat, S | |
dc.date.accessioned | 2021-11-25T14:42:20Z | |
dc.date.available | 2021-11-25T14:42:20Z | |
dc.date.issued | 2021-09-01 | |
dc.identifier.citation | JTO clinical and research reports, 2021, 2 (9), pp. 100213 - ? | |
dc.identifier.issn | 2666-3643 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4901 | |
dc.identifier.eissn | 2666-3643 | |
dc.identifier.doi | 10.1016/j.jtocrr.2021.100213 | |
dc.description.abstract | Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first case of life-threatening hepatitis in a patient with NSCLC shortly after commencing sotorasib, in which biopsy result was consistent with checkpoint inhibitor (CPI) immune-related adverse event, implicating sotorasib as being able to trigger CPI immune hepatitis. Given the large proportion of patients potentially treatable with sequential sotorasib after CPI, coupled with limited trial data, sotorasib-triggered CPI immune-related hepatitis should be considered in patients with sotorasib hepatotoxicity. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 100213 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Severe Immune Checkpoint Inhibitor Hepatitis in KRAS G12C-Mutant NSCLC Potentially Triggered by Sotorasib: Case Report. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-07-19 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.jtocrr.2021.100213 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | JTO clinical and research reports | |
pubs.issue | 9 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.) | |
pubs.publication-status | Published | |
pubs.volume | 2 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Thoracic Oncology | |
dc.contributor.icrauthor | Popat, Sanjay | |