Severe Immune Checkpoint Inhibitor Hepatitis in KRAS G12C-Mutant NSCLC Potentially Triggered by Sotorasib: Case Report.
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Date
2021-09-01ICR Author
Author
Begum, P
Goldin, RD
Possamai, LA
Popat, S
Type
Journal Article
Metadata
Show full item recordAbstract
Sotorasib is a first-in-class small molecule that irreversibly inhibits KRAS G12C, locking it in an inactive state, inhibiting oncogenic signaling, and inducing a proinflammatory microenvironment. Here, we report the first case of life-threatening hepatitis in a patient with NSCLC shortly after commencing sotorasib, in which biopsy result was consistent with checkpoint inhibitor (CPI) immune-related adverse event, implicating sotorasib as being able to trigger CPI immune hepatitis. Given the large proportion of patients potentially treatable with sequential sotorasib after CPI, coupled with limited trial data, sotorasib-triggered CPI immune-related hepatitis should be considered in patients with sotorasib hepatotoxicity.
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Research team
Thoracic Oncology
Language
eng
Date accepted
2021-07-19
Citation
JTO clinical and research reports, 2021, 2 (9), pp. 100213 - ?
Publisher
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