dc.contributor.author | Curcean, S | |
dc.contributor.author | Cheng, L | |
dc.contributor.author | Picchia, S | |
dc.contributor.author | Tunariu, N | |
dc.contributor.author | Collins, D | |
dc.contributor.author | Blackledge, M | |
dc.contributor.author | Popat, S | |
dc.contributor.author | O'Brien, M | |
dc.contributor.author | Minchom, A | |
dc.contributor.author | Leach, MO | |
dc.contributor.author | Koh, D-M | |
dc.date.accessioned | 2022-01-06T14:42:31Z | |
dc.date.available | 2022-01-06T14:42:31Z | |
dc.date.issued | 2021-12-01 | |
dc.identifier.citation | JTO clinical and research reports, 2021, 2 (12), pp. 100253 - ? | |
dc.identifier.issn | 2666-3643 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4937 | |
dc.identifier.eissn | 2666-3643 | |
dc.identifier.doi | 10.1016/j.jtocrr.2021.100253 | |
dc.description.abstract | INTRODUCTION: We compared the magnetic resonance imaging total tumor volume (TTV) and median apparent diffusion coefficient (ADC) of malignant pleural mesothelioma (MPM) before and at 4 weeks after chemotherapy, to evaluate whether these are potential early markers of treatment response. METHODS: Diffusion-weighted magnetic resonance imaging was performed in 23 patients with MPM before and after 4 weeks of chemotherapy. The TTV was measured by semiautomatic segmentation (GrowCut) and transferred onto ADC maps to record the median ADC. Test-retest repeatability of TTV and ADC was evaluated in eight patients. TTV and median ADC changes were compared between responders and nonresponders, defined using modified Response Evaluation Criteria In Solid Tumors on computed tomography (CT) at 12 weeks after treatment. TTV and median ADC were also correlated with CT size measurement and disease survival. RESULTS: The test-retest 95% limits of agreement for TTV were -13.9% to 16.2% and for median ADC -1.2% to 3.3%. A significant increase in median ADC in responders was observed at 4 weeks after treatment (p = 0.02). Correlation was found between CT tumor size change at 12 weeks and median ADC changes at 4 weeks post-treatment (r = -0.560, p = 0.006). An increase in median ADC greater than 5.1% at 4 weeks has 100% sensitivity and 90% specificity for responders (area under the curve = 0.933, p < 0.001). There was also moderate correlation between median tumor ADC at baseline and overall survival (r = 0.45, p = 0.03). CONCLUSIONS: Diffusion-weighted magnetic resonance imaging measurements of TTV and median ADC in MPM have good measurement repeatability. Increase in ADC at 4 weeks post-treatment has the potential to be an early response biomarker. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 100253 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.title | Early Response to Chemotherapy in Malignant Pleural Mesothelioma Evaluated Using Diffusion-Weighted Magnetic Resonance Imaging: Initial Observations. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-10-27 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.jtocrr.2021.100253 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | JTO clinical and research reports | |
pubs.issue | 12 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/The Adult Drug Development Unit at the ICR and the RM | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Thoracic Oncology/Thoracic Oncology (hon.) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.publication-status | Published | |
pubs.volume | 2 | |
pubs.embargo.terms | Not known | |
icr.researchteam | The Adult Drug Development Unit at the ICR and the RM | |
icr.researchteam | Thoracic Oncology | |
icr.researchteam | Radiotherapy Physics Modelling | |
dc.contributor.icrauthor | Collins, David | |
dc.contributor.icrauthor | Minchom, Anna | |