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Understanding and overcoming tumor heterogeneity in metastatic breast cancer treatment.

dc.contributor.authorPasha, N
dc.contributor.authorTurner, NC
dc.date.accessioned2022-01-12T15:12:50Z
dc.date.available2022-01-12T15:12:50Z
dc.date.issued2021-07-19
dc.identifierhttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000675896600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=d4b848928d1c3e5c86d298abb68475f9
dc.identifier.citationNATURE CANCER, 2021, 2 (7), pp. 680 - 692 (13)
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4956
dc.identifier.eissn2662-1347
dc.identifier.eissn2662-1347
dc.identifier.doi10.1038/s43018-021-00229-1
dc.identifier.doi10.1038/s43018-021-00229-1
dc.description.abstractRational development of targeted therapies has revolutionized metastatic breast cancer outcomes, although resistance to treatment remains a major challenge. Advances in molecular profiling and imaging technologies have provided evidence for the impact of clonal diversity in cancer treatment resistance, through the outgrowth of resistant clones. In this Review, we focus on the genomic processes that drive tumoral heterogeneity and the mechanisms of resistance underlying metastatic breast cancer treatment and discuss implications for future treatment strategies.
dc.format.extent680 - 692 (13)
dc.languageEnglish
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserved
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectOncology
dc.subjectFIRST-LINE THERAPY
dc.subjectPHASE-III
dc.subjectTRASTUZUMAB EMTANSINE
dc.subjectPOSTMENOPAUSAL WOMEN
dc.subjectCLONAL EVOLUTION
dc.subjectESR1 MUTATIONS
dc.subjectDOUBLE-BLIND
dc.subjectINTRATUMOR HETEROGENEITY
dc.subjectARTIFICIAL-INTELLIGENCE
dc.subjectMOLECULAR PORTRAITS
dc.titleUnderstanding and overcoming tumor heterogeneity in metastatic breast cancer treatment.
dc.typeJournal Article
dcterms.dateAccepted2021-06-02
rioxxterms.versionAM
rioxxterms.versionofrecord10.1038/s43018-021-00229-1
rioxxterms.licenseref.startdate2021-07-19
dc.relation.isPartOfNATURE CANCER
pubs.issue7
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Molecular Oncology
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/19/20 Starting Cohort
pubs.publication-statusPublished
pubs.volume2
pubs.embargo.termsNot known
icr.researchteamMolecular Oncology
dc.contributor.icrauthorPasha, Nida
dc.contributor.icrauthorTurner, Nicholas


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