Now showing items 1-8 of 8

    • Dichloroacetate induces autophagy in colorectal cancer cells and tumours. 

      Lin, G; Hill, DK; Andrejeva, G; Boult, JKR; Troy, H; Fong, A-CLFWT; Orton, MR; Panek, R; Parkes, HG; Jafar, M; Koh, D-M; Robinson, SP; Judson, IR; Griffiths, JR; Leach, MO; Eykyn, TR; Chung, Y-L (2014-07)
      <h4>Background</h4>Dichloroacetate (DCA) has been found to have antitumour properties.<h4>Methods</h4>We investigated the cellular and metabolic responses to DCA treatment and recovery in human colorectal (HT29, HCT116 WT ...
    • Diffusion-weighted Imaging as a Treatment Response Biomarker for Evaluating Bone Metastases in Prostate Cancer: A Pilot Study. 

      Perez-Lopez, R; Mateo, J; Mossop, H; Blackledge, MD; Collins, DJ; Rata, M; Morgan, VA; Macdonald, A; Sandhu, S; Lorente, D; Rescigno, P; Zafeiriou, Z; Bianchini, D; Porta, N; Hall, E; Leach, MO; de Bono, JS; Koh, D-M; Tunariu, N (2017-04)
      Purpose To determine the usefulness of whole-body diffusion-weighted imaging (DWI) to assess the response of bone metastases to treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). Materials ...
    • Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models. 

      Wong Te Fong, A-C; Thavasu, P; Gagrica, S; Swales, KE; Leach, MO; Cosulich, SC; Chung, Y-L; Banerji, U (2017-12-06)
      Activation of the PI3K/mTOR pathway has been shown to be correlated with resistance to chemotherapy in ovarian cancer. We aimed to investigate the effects of combining inhibition of mTORC1 and 2 using the mTOR kinase ...
    • Extracranial Soft-Tissue Tumors: Repeatability of Apparent Diffusion Coefficient Estimates from Diffusion-weighted MR Imaging. 

      Winfield, JM; Tunariu, N; Rata, M; Miyazaki, K; Jerome, NP; Germuska, M; Blackledge, MD; Collins, DJ; de Bono, JS; Yap, TA; deSouza, NM; Doran, SJ; Koh, D-M; Leach, MO; Messiou, C; Orton, MR (2017-07)
      Purpose To assess the repeatability of apparent diffusion coefficient (ADC) estimates in extracranial soft-tissue diffusion-weighted magnetic resonance imaging across a wide range of imaging protocols and patient populations. ...
    • Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma. 

      Al-Saffar, NMS; Troy, H; Wong Te Fong, A-C; Paravati, R; Jackson, LE; Gowan, S; Boult, JKR; Robinson, SP; Eccles, SA; Yap, TA; Leach, MO; Chung, Y-L (2018-10-31)
      <h4>Background</h4>AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance spectroscopy (MRS) to assess whether inhibition of AKT ...
    • Noninvasive detection of carboxypeptidase G2 activity in vivo. 

      Jamin, Y; Smyth, L; Robinson, SP; Poon, ESC; Eykyn, TR; Springer, CJ; Leach, MO; Payne, GS (2011-05)
      The pseudomonad protein, carboxypeptidase G2 (CPG2), is a prodrug-activating enzyme utilized in the targeted chemotherapy strategies of antibody- and gene-directed enzyme prodrug therapy (ADEPT and GDEPT). We have developed ...
    • The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS). 

      Leach, MO; Eeles, RA; Turnbull, LW; Dixon, AK; Brown, J; Hoff, RJC; Coulthard, A; Dixon, JM; Easton, DF; Evans, DGR; Gilbert, FJ; Hawnaur, J; Hayes, C; Kessar, P; Lakhani, S; Liney, G; Moss, SM; Padhani, AP; Pointon, LJ; Sydenham, M; Walker, LG; Warren, RML; Haites, NE; Morrison, P; Cole, T; Rayter, Z; Donaldson, A; Shere, M; Rankin, J; Goudie, D; Steel, CM; Davidson, R; Chu, C; Ellis, I; Mackay, J; Hodgson, SV; Homfray, T; Douglas, F; Quarrell, OW; Eccles, DM; Gilbert, FG; Crothers, G; Walker, CP; Jones, A; Slack, N; Britton, P; Sheppard, DG; Walsh, J; Whitehouse, G; Teh, W; Rankin, S; Boggis, C; Potterton, J; McLean, L; Gordon, PAL; Rubin, C; Magnetic Resonance Imaging as a Method of Screening for Breast Cancer Advisory Group (2002-09)
      The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS) is in progress. The study design, accrual to date, and related research projects are described. Revised accrual rates ...
    • Volume of Bone Metastasis Assessed with Whole-Body Diffusion-weighted Imaging Is Associated with Overall Survival in Metastatic Castration-resistant Prostate Cancer. 

      Perez-Lopez, R; Lorente, D; Blackledge, MD; Collins, DJ; Mateo, J; Bianchini, D; Omlin, A; Zivi, A; Leach, MO; de Bono, JS; Koh, D-M; Tunariu, N (2016-07)
      Purpose To determine the correlation between the volume of bone metastasis as assessed with diffusion-weighted (DW) imaging and established prognostic factors in metastatic castration-resistant prostate cancer (mCRPC) and ...