Volume of Bone Metastasis Assessed with Whole-Body Diffusion-weighted Imaging Is Associated with Overall Survival in Metastatic Castration-resistant Prostate Cancer.
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Date
2016-07-01Author
Perez-Lopez, R
Lorente, D
Blackledge, MD
Collins, DJ
Mateo, J
Bianchini, D
Omlin, A
Zivi, A
Leach, MO
de Bono, JS
Koh, D-M
Tunariu, N
Type
Journal Article
Metadata
Show full item recordAbstract
Purpose To determine the correlation between the volume of bone metastasis as assessed with diffusion-weighted (DW) imaging and established prognostic factors in metastatic castration-resistant prostate cancer (mCRPC) and the association with overall survival (OS). Materials and Methods This retrospective study was approved by the institutional review board; informed consent was obtained from all patients. The authors analyzed whole-body DW images obtained between June 2010 and February 2013 in 53 patients with mCRPC at the time of starting a new line of anticancer therapy. Bone metastases were identified and delineated on whole-body DW images in 43 eligible patients. Total tumor diffusion volume (tDV) was correlated with the bone scan index (BSI) and other prognostic factors by using the Pearson correlation coefficient (r). Survival analysis was performed with Kaplan-Meier analysis and Cox regression. Results The median tDV was 503.1 mL (range, 5.6-2242 mL), and the median OS was 12.9 months (95% confidence interval [CI]: 8.7, 16.1 months). There was a significant correlation between tDV and established prognostic factors, including hemoglobin level (r = -0.521, P < .001), prostate-specific antigen level (r = 0.556, P < .001), lactate dehydrogenase level (r = 0.534, P < .001), alkaline phosphatase level (r = 0.572, P < .001), circulating tumor cell count (r = 0.613, P = .004), and BSI (r = 0.565, P = .001). A higher tDV also showed a significant association with poorer OS (hazard ratio, 1.74; 95% CI: 1.02, 2.96; P = .035). Conclusion Metastatic bone disease from mCRPC can be evaluated and quantified with whole-body DW imaging. Whole-body DW imaging-generated tDV showed correlation with established prognostic biomarkers and is associated with OS in mCRPC. (©) RSNA, 2016 Online supplemental material is available for this article.
Collections
Subject
Bone and Bones
Humans
Bone Neoplasms
Diffusion Magnetic Resonance Imaging
Disease-Free Survival
Tumor Burden
Proportional Hazards Models
Retrospective Studies
Reproducibility of Results
Adult
Aged
Aged, 80 and over
Middle Aged
Male
Whole Body Imaging
Kaplan-Meier Estimate
Prostatic Neoplasms, Castration-Resistant
Research team
Prostate Cancer Targeted Therapy Group
Computational Imaging
Magnetic Resonance
Language
eng
License start date
2016-07
Citation
Radiology, 2016, 280 (1), pp. 151 - 160
Publisher
RADIOLOGICAL SOC NORTH AMERICA