dc.contributor.author | Perez-Lopez, R | |
dc.contributor.author | Lorente, D | |
dc.contributor.author | Blackledge, MD | |
dc.contributor.author | Collins, DJ | |
dc.contributor.author | Mateo, J | |
dc.contributor.author | Bianchini, D | |
dc.contributor.author | Omlin, A | |
dc.contributor.author | Zivi, A | |
dc.contributor.author | Leach, MO | |
dc.contributor.author | de Bono, JS | |
dc.contributor.author | Koh, D-M | |
dc.contributor.author | Tunariu, N | |
dc.date.accessioned | 2016-12-12T13:40:02Z | |
dc.date.issued | 2016-07-01 | |
dc.identifier.citation | Radiology, 2016, 280 (1), pp. 151 - 160 | |
dc.identifier.issn | 0033-8419 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/323 | |
dc.identifier.eissn | 1527-1315 | |
dc.identifier.doi | 10.1148/radiol.2015150799 | |
dc.description.abstract | Purpose To determine the correlation between the volume of bone metastasis as assessed with diffusion-weighted (DW) imaging and established prognostic factors in metastatic castration-resistant prostate cancer (mCRPC) and the association with overall survival (OS). Materials and Methods This retrospective study was approved by the institutional review board; informed consent was obtained from all patients. The authors analyzed whole-body DW images obtained between June 2010 and February 2013 in 53 patients with mCRPC at the time of starting a new line of anticancer therapy. Bone metastases were identified and delineated on whole-body DW images in 43 eligible patients. Total tumor diffusion volume (tDV) was correlated with the bone scan index (BSI) and other prognostic factors by using the Pearson correlation coefficient (r). Survival analysis was performed with Kaplan-Meier analysis and Cox regression. Results The median tDV was 503.1 mL (range, 5.6-2242 mL), and the median OS was 12.9 months (95% confidence interval [CI]: 8.7, 16.1 months). There was a significant correlation between tDV and established prognostic factors, including hemoglobin level (r = -0.521, P < .001), prostate-specific antigen level (r = 0.556, P < .001), lactate dehydrogenase level (r = 0.534, P < .001), alkaline phosphatase level (r = 0.572, P < .001), circulating tumor cell count (r = 0.613, P = .004), and BSI (r = 0.565, P = .001). A higher tDV also showed a significant association with poorer OS (hazard ratio, 1.74; 95% CI: 1.02, 2.96; P = .035). Conclusion Metastatic bone disease from mCRPC can be evaluated and quantified with whole-body DW imaging. Whole-body DW imaging-generated tDV showed correlation with established prognostic biomarkers and is associated with OS in mCRPC. (©) RSNA, 2016 Online supplemental material is available for this article. | |
dc.format | Print-Electronic | |
dc.format.extent | 151 - 160 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | RADIOLOGICAL SOC NORTH AMERICA | |
dc.subject | Bone and Bones | |
dc.subject | Humans | |
dc.subject | Bone Neoplasms | |
dc.subject | Diffusion Magnetic Resonance Imaging | |
dc.subject | Disease-Free Survival | |
dc.subject | Tumor Burden | |
dc.subject | Proportional Hazards Models | |
dc.subject | Retrospective Studies | |
dc.subject | Reproducibility of Results | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Male | |
dc.subject | Whole Body Imaging | |
dc.subject | Kaplan-Meier Estimate | |
dc.subject | Prostatic Neoplasms, Castration-Resistant | |
dc.title | Volume of Bone Metastasis Assessed with Whole-Body Diffusion-weighted Imaging Is Associated with Overall Survival in Metastatic Castration-resistant Prostate Cancer. | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1148/radiol.2015150799 | |
rioxxterms.licenseref.startdate | 2016-07 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Radiology | |
pubs.issue | 1 | |
pubs.notes | 12 months | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Computational Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Prostate Cancer Targeted Therapy Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Computational Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 280 | |
pubs.embargo.terms | 12 months | |
icr.researchteam | Prostate Cancer Targeted Therapy Group | |
icr.researchteam | Computational Imaging | |
icr.researchteam | Magnetic Resonance | |
dc.contributor.icrauthor | Blackledge, Matthew | |
dc.contributor.icrauthor | Collins, David | |
dc.contributor.icrauthor | Leach, Martin | |
dc.contributor.icrauthor | De Bono, Johann | |