Showing items related by title, author, creator and subject.

• A caveolin-dependent and PI3K/AKT-independent role of PTEN in beta-catenin transcriptional activity 

  Pendersen, Malin; Pedersen, Malin (2015-08)

  Loss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss ...
• Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma. 

  Bol, KF; van den Bosch, T; Schreibelt, G; Mensink, HW; Keunen, JEE; Kiliç, E; Japing, WJ; Geul, KW; Westdorp, H; Boudewijns, S; Croockewit, SAJ; van Rossum, MM; de Goede, AL; Naus, NC; van der Graaf, WTA; Gerritsen, WR; de Klein, A; Punt, CJA; Figdor, CG; Cohen, VM; Paridaens, D; de Vries, IJM (2016-10)
• Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. 

  Lechertier, T; Reynolds, LE; Kim, H; Pedrosa, AR; Gómez-Escudero, J; Muñoz-Félix, JM; Batista, S; Dukinfield, M; Demircioglu, F; Wong, PP; Matchett, KP; Henderson, NC; D'Amico, G; Parsons, M; Harwood, C; Meier, P; Hodivala-Dilke, KM (2020-06-04)

  The overexpression of the protein tyrosine kinase, Focal adhesion kinase (FAK), in endothelial cells has implicated its requirement in angiogenesis and tumour growth, but how pericyte FAK regulates tumour angiogenesis is ...