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dc.contributor.authorWalker, MD
dc.contributor.authorGear, JI
dc.contributor.authorCraig, AJ
dc.contributor.authorMcGowan, DR
dc.date.accessioned2022-04-01T11:01:59Z
dc.date.available2022-04-01T11:01:59Z
dc.date.issued2022-01-14
dc.identifier.citationDiagnostics (Basel, Switzerland), 2022, 12 (1)
dc.identifier.issn2075-4418
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5060
dc.identifier.eissn2075-4418
dc.identifier.eissn2075-4418
dc.identifier.doi10.3390/diagnostics12010194
dc.identifier.doi10.3390/diagnostics12010194
dc.description.abstractRespiratory motion degrades the quantification accuracy of PET imaging by blurring the radioactivity distribution. In the case of post-SIRT PET-CT verification imaging, respiratory motion can lead to inaccuracies in dosimetric measures. Using an anthropomorphic phantom filled with 90Y at a range of clinically relevant activities, together with a respiratory motion platform performing realistic motions (10-15 mm amplitude), we assessed the impact of respiratory motion on PET-derived post-SIRT dosimetry. Two PET scanners at two sites were included in the assessment. The phantom experiments showed that device-driven quiescent period respiratory motion correction improved the accuracy of the quantification with statistically significant increases in both the mean contrast recovery (+5%, p = 0.003) and the threshold activities corresponding to the dose to 80% of the volume of interest (+6%, p < 0.001). Although quiescent period gating also reduces the number of counts and hence increases the noise in the PET image, its use is encouraged where accurate quantification of the above metrics is desired.
dc.formatElectronic
dc.languageeng
dc.language.isoeng
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleEffects of Respiratory Motion on Y-90 PET Dosimetry for SIRT.
dc.typeJournal Article
dcterms.dateAccepted2022-01-10
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3390/diagnostics12010194
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2022-01-14
dc.relation.isPartOfDiagnostics (Basel, Switzerland)
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radioisotope Physics
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/14/15 Starting Cohort
pubs.publication-statusPublished
pubs.volume12
pubs.embargo.termsNot known
icr.researchteamRadioisotope Physics
dc.contributor.icrauthorGear, Jonathan
dc.contributor.icrauthorCraig, Allison


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/