dc.contributor.author | In 't Veld, EH | |
dc.contributor.author | Keizer, R | |
dc.contributor.author | Post, N | |
dc.contributor.author | Versteeg, J | |
dc.contributor.author | Verdijk, R | |
dc.contributor.author | Naus, N | |
dc.contributor.author | Relyveld, G | |
dc.contributor.author | Crijns, M | |
dc.contributor.author | Smith, M | |
dc.contributor.author | Grünhagen, D | |
dc.contributor.author | Wakkee, M | |
dc.contributor.author | Paridaens, D | |
dc.contributor.author | Zavrakidis, I | |
dc.contributor.author | Mooyaart, A | |
dc.contributor.author | van Akkooi, A | |
dc.contributor.author | Strauss, D | |
dc.contributor.author | Verhoef, C | |
dc.contributor.author | Wouters, M | |
dc.contributor.author | Hayes, A | |
dc.contributor.author | van Houdt, W | |
dc.date.accessioned | 2022-04-01T13:36:04Z | |
dc.date.available | 2022-04-01T13:36:04Z | |
dc.date.issued | 2022-03-01 | |
dc.identifier.citation | Journal of surgical oncology, 2022, 125 (4), pp. 730 - 735 | |
dc.identifier.issn | 0022-4790 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/5062 | |
dc.identifier.eissn | 1096-9098 | |
dc.identifier.eissn | 1096-9098 | |
dc.identifier.doi | 10.1002/jso.26774 | |
dc.identifier.doi | 10.1002/jso.26774 | |
dc.description.abstract | BACKGROUND: Sebaceous carcinoma (SC) is a rare malignant tumour whereby, comprehensive long-term data are scarce. This study aimed to assess the outcome of patients treated with resection for SC. METHODS: Patients treated at four tertiary centres were included. Cumulative incidence curves were calculated for recurrences. RESULTS: A total of 100 patients (57 males, 57%) were included with 103 SCs. The median age was 72 (range, 15-95) years with a median follow-up of 52 (interquartile range [IQR], 24-93) months. Most SCs were located (peri)ocular (49.5%). Of all SCs, 17 locally recurred (16.5%) with a median time to recurrence of 19 (IQR, 8-29) months. The cumulative incidence probability for recurrence was statistically higher for (peri)ocular tumours (p = 0.005), and for positive resection margins (p = 0.001). Two patients presented with lymph node metastases and additional seven patients (8.7%) developed lymph node metastases during follow-up with a median time to metastases of 8 (IQR, 0.5-28) months. Three patients had concurrent in-transit metastases and one patient also developed liver and bone metastases during follow-up. CONCLUSION: SC is a rare, yet locally aggressive tumour. Positive resection margins and (peri)ocular SCs are more frequently associated with local recurrence. SC infrequently presents with locoregional or distant metastases. | |
dc.format | Print-Electronic | |
dc.format.extent | 730 - 735 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0 | |
dc.subject | Humans | |
dc.subject | Adenocarcinoma, Sebaceous | |
dc.subject | Eye Neoplasms | |
dc.subject | Sebaceous Gland Neoplasms | |
dc.subject | Lymphatic Metastasis | |
dc.subject | Neoplasm Recurrence, Local | |
dc.subject | Prognosis | |
dc.subject | Retrospective Studies | |
dc.subject | Follow-Up Studies | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Young Adult | |
dc.title | Outcome after treatment for sebaceous carcinoma: A multicenter study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-10-15 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1002/jso.26774 | |
dc.relation.isPartOf | Journal of surgical oncology | |
pubs.issue | 4 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Sarcoma and Melanoma Surgery | |
pubs.publication-status | Published | |
pubs.volume | 125 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Sarcoma and Melanoma Surgery | |
dc.contributor.icrauthor | Smith, Myles | |