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dc.contributor.authorMouratidis, PXE
dc.contributor.authorTer Haar, G
dc.date.accessioned2022-04-14T13:43:35Z
dc.date.available2022-04-14T13:43:35Z
dc.date.issued2022-01-27
dc.identifier.citationCancers, 2022, 14 (3)en
dc.identifier.issn2072-6694
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5087
dc.identifier.eissn2072-6694en_US
dc.identifier.eissn2072-6694
dc.identifier.doi10.3390/cancers14030638en_US
dc.identifier.doi10.3390/cancers14030638
dc.description.abstractTraditional oncological interventions have failed to improve survival for pancreatic cancer patients significantly. Novel treatment modalities able to release cancer-specific antigens, render immunologically "cold" pancreatic tumours "hot" and disrupt or reprogram the pancreatic tumour microenvironment are thus urgently needed. Therapeutic focused ultrasound exerts thermal and mechanical effects on tissue, killing cancer cells and inducing an anti-cancer immune response. The most important advances in therapeutic focused ultrasound use for initiation and augmentation of the cancer immunity cycle against pancreatic cancer are described. We provide a comprehensive review of the use of therapeutic focused ultrasound for the treatment of pancreatic cancer patients and describe recent studies that have shown an ultrasound-induced anti-cancer immune response in several tumour models. Published studies that have investigated the immunological effects of therapeutic focused ultrasound in pancreatic cancer are described. This article shows that therapeutic focused ultrasound has been deemed to be a safe technique for treating pancreatic cancer patients, providing pain relief and improving survival rates in pancreatic cancer patients. Promotion of an immune response in the clinic and sensitisation of tumours to the effects of immunotherapy in preclinical models of pancreatic cancer is shown, making it a promising candidate for use in the clinic.en_US
dc.formatElectronicen_US
dc.languageengen_US
dc.language.isoengen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleLatest Advances in the Use of Therapeutic Focused Ultrasound in the Treatment of Pancreatic Cancer.en
dc.typeJournal Article
dcterms.dateAccepted2022-01-19
rioxxterms.versionVoRen
rioxxterms.versionofrecord10.3390/cancers14030638en
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en
rioxxterms.licenseref.startdate2022-01-27
dc.relation.isPartOfCancersen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound
pubs.publication-statusPublisheden_US
pubs.volume14en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTherapeutic Ultrasound
dc.contributor.icrauthorTer Haar, Gailen_US
dc.contributor.icrauthorMouratidis, Petrosen_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/