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dc.contributor.authorFournier, L
dc.contributor.authorde Geus-Oei, L-F
dc.contributor.authorRegge, D
dc.contributor.authorOprea-Lager, D-E
dc.contributor.authorD'Anastasi, M
dc.contributor.authorBidaut, L
dc.contributor.authorBäuerle, T
dc.contributor.authorLopci, E
dc.contributor.authorCappello, G
dc.contributor.authorLecouvet, F
dc.contributor.authorMayerhoefer, M
dc.contributor.authorKunz, WG
dc.contributor.authorVerhoeff, JJC
dc.contributor.authorCaruso, D
dc.contributor.authorSmits, M
dc.contributor.authorHoffmann, R-T
dc.contributor.authorGourtsoyianni, S
dc.contributor.authorBeets-Tan, R
dc.contributor.authorNeri, E
dc.contributor.authordeSouza, NM
dc.contributor.authorDeroose, CM
dc.contributor.authorCaramella, C
dc.date.accessioned2022-06-01T11:57:17Z
dc.date.available2022-06-01T11:57:17Z
dc.date.issued2022-01-10
dc.identifier.citationFrontiers in oncology, 2021, 11 pp. 800547 - ?
dc.identifier.issn2234-943X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5168
dc.identifier.eissn2234-943X
dc.identifier.eissn2234-943X
dc.identifier.doi10.3389/fonc.2021.800547
dc.identifier.doi10.3389/fonc.2021.800547
dc.description.abstractResponse evaluation criteria in solid tumours (RECIST) v1.1 are currently the reference standard for evaluating efficacy of therapies in patients with solid tumours who are included in clinical trials, and they are widely used and accepted by regulatory agencies. This expert statement discusses the principles underlying RECIST, as well as their reproducibility and limitations. While the RECIST framework may not be perfect, the scientific bases for the anticancer drugs that have been approved using a RECIST-based surrogate endpoint remain valid. Importantly, changes in measurement have to meet thresholds defined by RECIST for response classification within thus partly circumventing the problems of measurement variability. The RECIST framework also applies to clinical patients in individual settings even though the relationship between tumour size changes and outcome from cohort studies is not necessarily translatable to individual cases. As reproducibility of RECIST measurements is impacted by reader experience, choice of target lesions and detection/interpretation of new lesions, it can result in patients changing response categories when measurements are near threshold values or if new lesions are missed or incorrectly interpreted. There are several situations where RECIST will fail to evaluate treatment-induced changes correctly; knowledge and understanding of these is crucial for correct interpretation. Also, some patterns of response/progression cannot be correctly documented by RECIST, particularly in relation to organ-site (e.g. bone without associated soft-tissue lesion) and treatment type (e.g. focal therapies). These require specialist reader experience and communication with oncologists to determine the actual impact of the therapy and best evaluation strategy. In such situations, alternative imaging markers for tumour response may be used but the sources of variability of individual imaging techniques need to be known and accounted for. Communication between imaging experts and oncologists regarding the level of confidence in a biomarker is essential for the correct interpretation of a biomarker and its application to clinical decision-making. Though measurement automation is desirable and potentially reduces the variability of results, associated technical difficulties must be overcome, and human adjudications may be required.
dc.formatElectronic-eCollection
dc.format.extent800547 - ?
dc.languageeng
dc.language.isoeng
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleTwenty Years On: RECIST as a Biomarker of Response in Solid Tumours an EORTC Imaging Group - ESOI Joint Paper.
dc.typeJournal Article
dcterms.dateAccepted2021-11-30
rioxxterms.versionVoR
rioxxterms.versionofrecord10.3389/fonc.2021.800547
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
dc.relation.isPartOfFrontiers in oncology
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublished
pubs.volume11
pubs.embargo.termsNo embargo
icr.researchteamMagnetic Resonance
dc.contributor.icrauthordeSouza, Nandita


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