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dc.contributor.authorPayne, GS
dc.contributor.authorHarris, LM
dc.contributor.authorCairns, GS
dc.contributor.authorMessiou, C
dc.contributor.authordeSouza, NM
dc.contributor.authorMacdonald, A
dc.contributor.authorSaran, F
dc.contributor.authorLeach, MO
dc.date.accessioned2016-08-16T16:52:25Z
dc.date.issued2016-10
dc.identifier.citationNMR in biomedicine, 2016, 29 (10), pp. 1420 - 1426
dc.identifier.issn0952-3480
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/52
dc.identifier.eissn1099-1492
dc.identifier.doi10.1002/nbm.3587
dc.description.abstract(1) H MRS measurements of lactate are often confounded by overlapping lipid signals. Double-quantum (DQ) filtering eliminates lipid signals and permits single-shot measurements, which avoid subtraction artefacts in moving tissues. This study evaluated a single-voxel-localized DQ filtering method qualitatively and quantitatively for measuring lactate concentrations in the presence of lipid, using high-grade brain tumours in which the results could be compared with standard acquisition as a reference. Paired standard acquisition and DQ-filtered (1) H MR spectra were acquired at 3T from patients receiving treatment for glioblastoma, using fLASER (localization by adiabatic selective refocusing using frequency offset corrected inversion pulses) single-voxel localization. Data were acquired from 2 × 2 × 2 cm(3) voxels, with a repetition time of 1 s and 128 averages (standard acquisition) or 256 averages (DQ-filtered acquisition), requiring 2.15 and 4.3 min respectively. Of 37 evaluated data pairs, 20 cases (54%) had measureable lactate (fitted Cramér-Rao lower bounds ≤ 20%) in either the DQ-filtered or the standard acquisition spectra. The measured DQ-filtered lactate signal was consistently downfield of lipid (1.33 ± 0.03 ppm vs 1.22 ± 0.08 ppm; p = 0.002), showing that it was not caused by lipid breakthrough, and that it matched the lactate signal seen in standard measurements (1.36 ± 0.02 ppm). In the absence of lipid, similar lactate concentrations were measured by the two methods (mean ratio DQ filtered/standard acquisition = 1.10 ± 0.21). In 7/20 cases with measurable lactate, signal was not measureable in the standard acquisition owing to lipid overlap but was quantified in the DQ-filtered acquisition. Conversely, lactate was undetected in seven DQ-filtered acquisitions but visible using the standard acquisition. In conclusion, the DQ filtering method has proven robust in eliminating lipid and permits uncontaminated measurement of lactate. This is important validation prior to use in tissues outside the brain, which contain large amounts of lipid and which are often susceptible to motion.
dc.formatPrint-Electronic
dc.format.extent1420 - 1426
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectBrain Neoplasms
dc.subjectLactic Acid
dc.subjectMagnetic Resonance Imaging
dc.subjectSensitivity and Specificity
dc.subjectReproducibility of Results
dc.subjectAlgorithms
dc.subjectSignal Processing, Computer-Assisted
dc.subjectMolecular Imaging
dc.subjectNeoplasm Grading
dc.subjectProton Magnetic Resonance Spectroscopy
dc.subjectBiomarkers, Tumor
dc.titleValidating a robust double-quantum-filtered (1) H MRS lactate measurement method in high-grade brain tumours.
dc.typeJournal Article
dcterms.dateAccepted2016-06-23
rioxxterms.versionofrecord10.1002/nbm.3587
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2016-10
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNMR in biomedicine
pubs.issue10
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.publication-statusPublished
pubs.volume29
pubs.embargo.termsNo embargo
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorPayne, Geoffreyen
dc.contributor.icrauthordeSouza, Nanditaen
dc.contributor.icrauthorLeach, Martinen
dc.contributor.icrauthorMessiou, Christinaen


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