Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study.
View/ Open
Date
2016-08ICR Author
Author
Pugh, SA
Bowers, M
Ball, A
Falk, S
Finch-Jones, M
Valle, JW
O'Reilly, DA
Siriwardena, AK
Hornbuckle, J
Rees, M
Rees, C
Iveson, T
Hickish, T
Maishman, T
Stanton, L
Dixon, E
Corkhill, A
Radford, M
Garden, OJ
Cunningham, D
Maughan, TS
Bridgewater, JA
Primrose, JN
Type
Journal Article
Metadata
Show full item recordAbstract
Background The addition of cetuximab (CTX) to perioperative chemotherapy (CT) for operable colorectal liver metastases resulted in a shorter progression-free survival. Details of disease progression are described to further inform the primary study outcome.Methods A total of 257 KRAS wild-type patients were randomised to CT alone or CT with CTX. Data regarding sites and treatment of progressive disease were obtained for the 109 (CT n=48, CT and CTX n=61) patients with progressive disease at the cut-off date for analysis of November 2012.Results The liver was the most frequent site of progression (CT 67% (32/48); CT and CTX 66% (40/61)). A higher proportion of patients in the CT and group had multiple sites of progressive disease (CT 8%, 4/48; CT and CTX 23%, 14/61 P=0.04). Further treatment for progressive disease is known for 84 patients of whom 69 received further CT, most frequently irinotecan based. Twenty-two patients, 11 in each arm, received CTX as a further line agent.Conclusions Both the distribution of progressive disease and further treatment are as expected for such a cohort. The pattern of disease progression seen is consistent with failure of systemic micrometastatic disease control rather than failure of local disease control following liver surgery.
Collections
Subject
Humans
Colorectal Neoplasms
Liver Neoplasms
Disease Progression
Organoplatinum Compounds
Camptothecin
Leucovorin
Antineoplastic Combined Chemotherapy Protocols
Disease-Free Survival
Neoadjuvant Therapy
Hepatectomy
Aged
Middle Aged
Female
Male
Metastasectomy
Capecitabine
Cetuximab
Irinotecan
Oxaliplatin
Research team
Medicine (RMH Smith Cunningham)
Language
eng
Date accepted
2016-06-13
License start date
2016-08
Citation
British journal of cancer, 2016, 115 (4), pp. 420 - 424